38367-40-7

Usage

InChI:InChI=1/C15H10ClNO/c16-15-13(10-18)12-8-4-5-9-14(12)17(15)11-6-2-1-3-7-11/h1-10H

Upstream product

• 3335-98-6 1-phenyl-1,3-dihydro-indol-2-one 
• 68-12-2 N,N-dimethyl-formamide 
• 5428-43-3 2-chloro-N,N-diphenylacetamide 
• 122-39-4 diphenylamine 
• 5059-30-3 2-chloroindole-3-carboxaldehyde 
• 98-80-6 phenylboronic acid 

Downstream Products

• 68096-65-1 2-Chloro-1-phenyl-1H-indole-3-carbaldehyde oxime 
• 116885-04-2 2-Azido-3-formyl-1-phenylindole 
• 139347-76-5 2-oxo-1-phenylindoline-3-carbonitrile 
• 675580-78-6 1-phenyl-2-(imidazol-1-yl)-3-formylindole 
• 126177-50-2 2-Amino-1-phenyl-1H-indole-3-carbaldehyde 
• 120110-26-1 2-Chloro-1-phenyl-1H-indole-3-carbaldehyde O-(2,4-dinitro-phenyl)-oxime 
• 70500-34-4 2-[4-(2-hydroxy-ethyl)-piperazin-1-yl]-1-phenyl-indole-3-carbaldehyde 
• 847801-52-9 1-phenyl-2-(thiomorphin-4-yl)-1H-indole-3-carboxaldehyde 

Relevant academic research and scientific papers

Discovery and optimization of a new class of potent and non-chiral indole-3-carboxamide-based renin inhibitors

Selective inhibition of the aspartyl protease renin has gained attraction as an interesting approach to control hypertension and associated cardiovascular risk factors given its unique position in the renin-angiotensin system. Using a combination of high-throughput screening, parallel synthesis, X-ray crystallography and structure-based design, we identified and optimized a novel series of potent and non-chiral indole-3-carboxamides with remarkable potency for renin. The most potent compound 5k displays an IC50 value of 2 nM.

Substituted indoles as inhibitors of poly (ADP-ribose) polymerase (PARP)

The present invention relates to a series of substituted indole derivatives of the formula I: wherein R, R1, R2, R3, R4, X and Y are as defined herein. This invention also relates to methods of making these compounds. The compounds of this invention are inhibitors of poly(adenosine 5′-diphosphate ribose) polymerase (PARP) and are therefore useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of diseases, including diseases associated with the central nervous system and cardiovascular disorders.

Synthesis and antimicrobial activities of some imidazole substituted indoles

The compounds 1-substituted 2-(imidazol-1-yl)-3-(4,5-diarylimidazol-2-yl) indoles 2, 1-substituted 2-(imidazol-1-yl)-3-(phenanthro[9,10-d]imidazol-2-yl) indoles 3 and 1-substituted 2-(imidazol-1-yl)-3-(benzimidazol-2-yl)indoles 4 have been synthesized from 1-substituted 2-(imidazol-1-yl)-3-formylindole 1. The structural elucidation of the synthesised compounds has been performed by IR, 1H NMR and mass spectroscopic data and elemental analyses. Antimicrobial activities of the compounds are examined and notable antifungal activity is obtained from some of the compounds as expected in comparison with the control agent ketoconazole.