54779-85-0

Upstream product

• 1147550-11-5 ammonium thiocyanate 
• 6068-72-0 4-cyanobenzoyl chlorIde 

Downstream Products

• 65343-57-9 O-Methyl N-(4-cyanobenzoyl)thiocarbamate 
• 845524-58-5 3-Butyl-2-[(Z)-4-cyano-benzoylimino]-4-methyl-2,3-dihydro-thiazole-5-carboxylic acid ethyl ester 
• 173338-88-0 1-(4-cyanobenzoyl)-3-isopropylthiourea 
• 845524-65-4 3-Benzyl-2-[(Z)-4-cyano-benzoylimino]-4-methyl-2,3-dihydro-thiazole-5-carboxylic acid ethyl ester 
• 174802-59-6 ethyl 3-benzyl-2-(4-cyanobenzoylimino)-4-methyl-3H-thiazoline-5-carboxylate 
• 174802-42-7 ethyl 3-n-butyl-2-(4-cyanobenzoylimino)-4-methyl-3H-thiazoline-5-carboxylate 

Relevant academic research and scientific papers

Copper promoted C-S and C-N cross-coupling Reactions:The synthesis of 2-(N-Aryolamino)benzothiazoles and 2-(N-Aryolamino)benzimidazoles

The synthesis of 2-(N-aryolamino)benzothiazoles and 2-(N-aryolamino)benzimidazoles has been accomplished in the presence of copper catalyst. These reactions involve C-S and C-N cross-coupling reaction. All electron donating and withdrawing substituent's readily underwent the reaction to give target products in good to excellent yield. In addition, the reaction also gave target product in high yield with bulk scale.

BENZIMIDAZOLE AND AZABENZIMIDAZOLE COMPOUNDS THAT INHIBIT ANAPLASTIC LYMPHOMA KINASE

Compounds of Formula (I) are useful inhibitors of anaplastic lymphoma kinase. Compounds of Formula (I) have the following structure: where the definitions of the variables are provided herein.

Design and synthesis of indole, 2,3-dihydro-indole, and 3,4-dihydro-2H-quinoline-1-carbothioic acid amide derivatives as novel HCV inhibitors

An efficient synthetic methodology to provide indole, 2,3-dihydro-indole, and 3,4-dihydro-2H-quinoline-1-carbothioic acid amide derivatives is described. These conformationally restricted heterobicyclic scaffolds were evaluated as a novel class of HCV inhibitors. Introduction of an acyl group at the NH2 of the thiourea moiety has been found to enhance inhibitory activity. The chain length and the position of the alkyl group on the indoline aromatic ring markedly influenced anti-HCV activity. The indoline scaffold was more potent than the corresponding indole and tetrahydroquinoline scaffolds and analogue 31 displayed excellent activity (EC50 = 510 nM) against HCV without significant cytotoxicity (CC50 >50 μM).

2-Acylimino-3-alkyl-3H-thiazoline derivatives: One-pot, three-component condensation synthesis of novel β-turn mimics

One-pot, three-component condensation of aroylthiourea, primary amine and α-halocarbonyl derivatives for the synthesis of 2-acylimino-3-alkyl-3H- thiazoline derivatives is described. This method is useful for simultaneously incorporating diverse functional groups at four positions in the 3H-thiazoline skeleton to obtain β-turn tripeptide mimics.

Thiazoline derivatives

Object: To provide compounds useful as inhibitors of blood platelet aggregation for intravenous administration. Constitution: A thiazoline derivative represented by the formula: STR1 ?wherein R1 is a hydroxyl group, an alkoxy group, a cycloalkoxy group or a group represented by the formula: R4 NH-- (wherein R4 is a cycloalkyl group), R2 is an alkyl group, a cycloalkyl group or a phenylalkyl group, R3 is a hydrogen atom or an alkyl group, and n is an integer of 2 to 9! or a salt thereof.