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• 159450-22-3 ethyl 2-(4-cyanobenzoylamino)-4-methylthiazole-5-carboxylate 
• 54779-85-0 4-cyanobenzoyl isothiocyanate 
• 100-46-9 benzylamine 
• 609-15-4 ethyl 2-chloro-3-oxo-butyrate 
• 6068-72-0 4-cyanobenzoyl chlorIde 

Relevant academic research and scientific papers

2-Acylimino-3-alkyl-3H-thiazoline derivatives: One-pot, three-component condensation synthesis of novel β-turn mimics

One-pot, three-component condensation of aroylthiourea, primary amine and α-halocarbonyl derivatives for the synthesis of 2-acylimino-3-alkyl-3H- thiazoline derivatives is described. This method is useful for simultaneously incorporating diverse functional groups at four positions in the 3H-thiazoline skeleton to obtain β-turn tripeptide mimics.

2-acylimino-3H-thiazoline derivatives: A novel template for platelet GPIIb/IIIa receptor antagonists

In the course of our research for the low-molecular weight RGD peptide mimics, we have found that a rigid 2-acylimino-3H-thiazoline structure is suitable for the peptide backbone mimics. Introduction of amidinophenyl and β-alanine moiety as arginine and aspartic acid side-chain surrogates to this backbone mimic resulted in a highly potent fibrinogen receptor antagonist 2-(4amidinobenzoylimino)-3,4-dimethyl-N-(2-carboxyethyl) -3H-thiazoline-5-carboxamide (7c), namely PS-028 (Ki = 46.5± 5.8 pM).