54782-51-3Relevant academic research and scientific papers
Methods for preparing benzo ring derivative with benzylic quaternary carbon center and ethazocine hydrobromide
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Paragraph 0201; 0202; 0203, (2018/10/11)
The invention provides methods for preparing a benzo ring derivative with a benzylic quaternary carbon center and ethazocine hydrobromide. An aryl iodide and an alkylating agent as starting materialsare stirred for reaction in an organic solvent at 30 DEG C to 120 DEG C under the action of a palladium catalyst, a phosphine ligand, a norbornene derivative, and a base to obtain the benzo ring derivative with the benzylic quaternary carbon center. The raw materials used in the method are cheap and easy to obtain, reaction conditions are mild, substrate universality is good, yield is high, and the preparation process is simple. Meanwhile, the present invention also provides a method for synthesizing an ethazocine hydrobromide compound based on a 1,2,3,4-tetrahydronaphthalene compound having abenzylic all-carbon quaternary carbon center synthesized by the method, the drug ethazocine hydrobromide for treatment of cancer pain and post-operative pain can be synthesized only by four steps. The method has short synthetic steps, simple operation and high total yield.
4-Benzazonine derivatives and process for preparation thereof
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, (2008/06/13)
Novel 4-Benzazonine derivatives and their salts, and processes for the preparation thereof are disclosed. These 4-benzazonine derivatives are represented by the following general formula: STR1 wherein R stands for --H, --OH or a lower alkoxy group such as
