548-29-8

Usage

Uses

Used in Pharmaceutical Industry:
(+)-ISOLARICIRESINOL is used as a therapeutic agent for its potential health benefits, such as its antioxidant and anti-inflammatory properties. It is particularly valuable for its potential to lower cholesterol levels and reduce the risk of hormone-related cancers, making it a candidate for the development of treatments in these areas.
Used in Nutraceutical Industry:
(+)-ISOLARICIRESINOL is used as a dietary supplement due to its presence in natural food sources like flaxseeds and sesame seeds. Its estrogen-like effects and potential health benefits position it as a valuable ingredient in nutraceutical products aimed at promoting overall health and well-being.
Used in Cosmetic Industry:
(+)-ISOLARICIRESINOL is used as an ingredient in cosmetic products for its antioxidant properties, which can help protect the skin from oxidative stress and potentially slow down the aging process, contributing to healthier and more youthful-looking skin.
Used in Functional Food Industry:
(+)-ISOLARICIRESINOL is used as an additive in functional foods to enhance their health-promoting properties. Its presence in these foods can provide consumers with the benefits of this bioactive compound, such as cholesterol reduction and anti-inflammatory effects, in addition to the nutritional value of the food itself.

Upstream product

• 111266-05-8 O-dibenzylisolariciresinol 
• 518-55-8 conidendrin 
• 486-29-3 lariciresinol 
• 2426-87-1 3-methoxy-4-(phenylmethoxy)benzaldehyde 
• 111266-03-6 (R)-(+)-3-(4-benzyloxy-3-methoxybenzyl)-γ-butyrolactone 
• 111266-00-3 (R)-4-<(4-hydroxy-3-methoxyphenyl)methyl>dihydro-2(3H)-furanone 
• 939963-12-9 (3S,4R)-4-(4-Benzyloxy-3-methoxy-benzyl)-3-[(4-benzyloxy-3-methoxy-phenyl)-hydroxy-methyl]-dihydro-furan-2-one 
• 111194-10-6 O-dibenzylretrodendrin 
• 111265-99-7 C₁₃H₁₄O₆^(2-)*2K⁽¹⁺⁾ 
• 5502-29-4 9,9'-Diacetoxy-guaja-cyclolign-7'-en-diacetat 
• 487-36-5 (+/-)-pinoresinol 

Downstream Products

• 5502-30-7 (+)-isolariciresinol teraacetate 
• 67560-72-9 (+)-Isolariciresinol-monomethylether 
• 21966-92-7 isolariciresinol dimethyl ether 
• 63320-66-1 phyltetralin 
• 116735-90-1 6-Methoxy-1-(3-methoxy-4-trimethylsilanyloxy-phenyl)-7-trimethylsilanyloxy-2,3-bis-trimethylsilanyloxymethyl-1,2,3,4-tetrahydro-naphthalene 

Relevant academic research and scientific papers

Total syntheses of schizandriside, saracoside and (±)-isolariciresinol with antioxidant activities

Lignans are widely distributed in plants and exhibit significant pharmacological effects, including anti-tumor and antioxidative activities. Here, we describe the total synthesis of schizandriside (1), a compound we previously isolated from Saraca asoca b

Synthetic transformation of hydroxymatairesinol from Norway spruce (picea abies) to 7-hydroxysecoisolariciresinol, (+)-lariciresinol and (+)-cyclolariciresinol

We have developed a method for the transformation of hydroxymatairesinol to optically pure (+)-lariciresinol and (+)-cyclolariciresinol via the hitherto unreported lignan 7-hydroxysecoisolariciresinol. The two naturally occurring isomers of hydroxymatairesinol were reduced with LiAlH4 to a mixture of two epimers of 7-hydroxysecoisolariciresinol, which were further selectively transformed to (+)-lariciresinol and (+)-cyclolariciresinol by an acid catalysed intramolecular cyclisation reaction. The structure of the major isomer of 7-hydroxysecoisolariciresinol was confirmed by X-ray crystallography and thereby also the absolute configurations of the two isomers of hydroxymatairesinol were unambiguously proven. Optical purities were determined by chiral HPLC-MS/MS and optical rotation measurements.

(+)-Isolarisiresinol 3a-O-sulphate from leaves of Myrsine seguinii

From leaves of Myrsine seguinii, (+)-isolarisiresinol 3a-O-β-D- glucopyranoside and 3a-O-sulphate were isolated. Their structures were elucidated by spectroscopic analyses.

Lignans from the roots of Urtica dioica and their metabolites bind to human sex hormone binding globulin (SHBG)

Polar extracts of the stinging nettle (Urtica dioica L) roots contain the lignans (+)-neoolivil, (-)-secoisolariciresinol, dehydrodiconiferyl alcohol, isolariciresinol, pinoresinol, and 3,4-divanillyltetrahydrofuran. These compounds were either isolated f

LIGNAN GLYCOSIDES FROM PARSONSIA LAEVIGATA

Bis-O-rhamnosides of lariciresinol, 5,5'-dimethoxylariciresinol, and secoisolariciresinol, and pinoresinolapiosyl(1->2)-glucoside were isolated from Parsonsia laevigata.Key Word Index - Parsonsia laevigata; Apocynaceae; lariciresinol; lignan rhamnoside; pinoresinol-apiosylglucoside.

THE SYNTHESES OF (R)-(+)-β-VANILLYL-γ-BUTYROLACTONE AND OF CHIRAL LIGNANS THEREFROM

(R)-(+)-β-vanillyl-γ-butyrolactone was obtained in 4 steps including a resolution, from vanillin and dimethyl succinate, and was used for the total syntheses of 5 naturally occurring and optically active lignans such as (+)-isolariciresinol 20.

DILIGNOL GLYCOSIDES FROM NEEDLES OF PICEA ABIES

(2R,3R)-2,3-dihydro-2-(4'-hydroxy-3'-methoxyphenyl)-3-(hydroxymethyl)-7-methoxy-5-benzofuranpropanol 4'-O-β-D-glucopyranoside , (2R,3R)-2,3-dihydro-7-hydroxy-2-(4'-hydroxy-3'-methoxyphenyl)-3-(hydroxymethyl)-5-benzofuranpropanol 4'-O-β-D-glucopyranoside and 4'-O-α-L-rhamnopyranoside, 1-(4'-hydroxy-3'-methoxyphenyl)-2--1,3-propanediol 1-O-β-D-glucopyranoside and 4'-O-β-D-xylopyranoside4, 2,3-bis-1,4-butanediol 1-O-β-D-glucopyranoside and (1R,2S,3S)-1,2,3,4-tetrahydro-7-hydroxy-1-(4'-hydroxy-3'-methoxyphenyl) -6-methoxy-2,3-naphthalenedimethanol α2-O-β-D-xylopyranoside have been isolated from needles of Picea abies and identified. - Keywords: Picea abies; Pinaceae; dilignol glycosides; dihydrodehydrodiconiferyl alcohol; ( - )-isolariciresinol.