54812-94-1Relevant academic research and scientific papers
Discovery of a Slow Tight Binding LPA1 Antagonist (ONO-0300302) for the Treatment of Benign Prostatic Hyperplasia
Terakado, Masahiko,Suzuki, Hidehiro,Hashimura, Kazuya,Tanaka, Motoyuki,Ueda, Hideyuki,Hirai, Keisuke,Asada, Masaki,Ikura, Masahiro,Matsunaga, Naoki,Saga, Hiroshi,Shinozaki, Koji,Karakawa, Naoko,Takada, Yuka,Minami, Masashi,Egashira, Hiromu,Sugiura, Yoshihiro,Yamada, Masanori,Nakade, Shinji,Takaoka, Yoshikazu
supporting information, p. 1281 - 1286 (2017/12/26)
Scaffold hopping from the amide group of lead compound ONO-7300243 (1) to a secondary alcohol successfully gave a novel chemotype lysophosphatidic acid receptor 1 (LPA1) antagonist 4. Wash-out experiments using rat isolated urethra showed that
