54828-05-6

Usage

Uses

Used in Pharmaceutical Industry:
1-METHYL-4-NITRO-1H-IMIDAZOLE-5-CARBOXYLIC ACID is used as a key intermediate in the synthesis of heteroxanthine, a compound with potential applications in the development of pharmaceuticals. Its unique structure allows for the creation of new drug candidates that can target specific biological pathways or receptors, contributing to the advancement of medicine and healthcare.
In the synthesis of heteroxanthine, 1-METHYL-4-NITRO-1H-IMIDAZOLE-5-CARBOXYLIC ACID plays a crucial role as a building block, enabling the formation of complex molecules with diverse therapeutic properties. Its versatility in chemical reactions and compatibility with other molecular components make it an essential component in the design and production of innovative pharmaceutical agents.

InChI:InChI=1/C5H5N3O4/c1-7-2-6-4(8(11)12)3(7)5(9)10/h2H,1H3,(H,9,10)

Upstream product

• 40648-96-2 1-methyl-4-nitro-1H-imidazole-5-carbonitrile 
• 89946-67-8 1-methyl-4-nitroimidazolyl-5-carboxylic acid methyl ester 
• 5413-88-7 5-Carboxamido-1-methyl-4-nitroimidazole 

Downstream Products

• 61982-14-7 1-methyl-4-nitroimidazolyl-5-carboxylic acid chloroanhydride 
• 32000-30-9 3-methyl-5-nitro-3H-imidazole-4-carboxylic acid hydrazide 
• 876935-29-4 [5-(3-methyl-5-nitro-3H-imidazol-4-yl)-[1,3,4]oxadiazol-2-yl]-m-tolyl-amine 
• 876935-23-8 (4-chloro-phenyl)-[5-(3-methyl-5-nitro-3H-imidazol-4-yl)-[1,3,4]oxadiazol-2-yl]-amine 
• 876935-30-7 (3-methoxy-phenyl)-[5-(3-methyl-5-nitro-3H-imidazol-4-yl)-[1,3,4]oxadiazol-2-yl]-amine 
• 876935-31-8 (2-methoxy-phenyl)-[5-(3-methyl-5-nitro-3H-imidazol-4-yl)-[1,3,4]oxadiazol-2-yl]-amine 
• 876935-32-9 [5-(3-methyl-5-nitro-3H-imidazol-4-yl)-[1,3,4]oxadiazol-2-yl]-o-tolyl-amine 
• 876935-38-5 (4-bromo-phenyl)-[5-(3-methyl-5-nitro-3H-imidazol-4-yl)-[1,3,4]oxadiazol-2-yl]-amine 
• 876935-25-0 (4-isopropyl-phenyl)-[5-(3-methyl-5-nitro-3H-imidazol-4-yl)-[1,3,4]oxadiazol-2-yl]-amine 
• 876935-36-3 (2-fluoro-4-methyl-phenyl)-[5-(3-methyl-5-nitro-3H-imidazol-4-yl)-[1,3,4]oxadiazol-2-yl]-amine 
• 876935-24-9 (4-tert-butyl-phenyl)-[5-(3-methyl-5-nitro-3H-imidazol-4-yl)-[1,3,4]oxadiazol-2-yl]-amine 

Relevant academic research and scientific papers

AROMATIC DERIVATIVES, PREPARATION METHODS, AND MEDICAL USES THEREOF

The present disclosure relates generally to aromatic derivatives that are inhibitors of FGFR4 and are useful in treating FGFR4-associated diseases or conditions. Compositions containing the compounds of the present disclosure are also provided.

SULFONAMIDE DERIVATIVE AND MEDICINAL USE THEREOF

Provided are sulfonamide derivatives of a specific chemical structure in which a sulfonamide group having, as a substituent, a phenyl group or a heterocyclic group having a hetero atom(s) as a constituent element(s) is present at its terminal, and pharmaceutically acceptable salts thereof. These compounds are novel compounds having excellent α4 integrin-inhibitory action.

ortho-Substituted azoles as selective and dual inhibitors of VEGF receptors 1 and 2

We have developed a series of novel potent ortho-substituted azole derivatives active against kinases VEGFR-1 and VEGFR-2. Both specific and dual ATP-competitive inhibitors of VEGFR-2 were identified. Kinase activity and selectivity could be controlled by varying the arylamido substituents at the azole ring. The most specific molecule (17) displayed >10-fold selectivity for VEGFR-2 over VEGFR-1. Compound activities in enzymatic and cell-based assays were in the range of activities for reported clinical and development candidates (IC50 30 × 10-5 cm/min) is indicative of their potential for intestinal absorption upon oral administration.

Hetaryl imidazoles: A novel dual inhibitors of VEGF receptors I and II

A novel potent derivatives of hetaryl imidazoles were described as inhibitors of vascular endothelial growth factor receptor II (VEGFR-2). Several compounds display VEGFR-2 inhibitory activity reaching IC50 100 nM in both enzymatic and cellular assays. The compounds also inhibit the related tyrosine kinase, VEGFR-1. By controlling the substitution pattern on the 5-carboxamido functionality, both dual and specific VEGFR-2 thiazoles were identified.

The Synthesis of Ring-expanded Analogues of Xanthine Containing the Imidazodiazepine Ring System

The synthesis of 4,5,7,8-tetrahydro-6H-imidazodiazepine-5,8-dione and its several 1- and 3-alkyl (aralkyl) derivatives 2 has been reported.Mechanistic explorations of the final synthetic step as well as structural confirmation of a final produ

MODELS FOR "FAT" NUCLEOSIDES AND NUCLEOTIDES: SYNTHESES OF "FAT" XANTHINE (fX), "FAT" GUANINE (fG), AND "FAT" HYPOXANTHINE (fHx) ANALOGUES OF THE IMIDAZODIAZEPINE SYSTEM

Synthetic analogues of xanthine, guanine, and hypoxanthine, possessing the skeletal structure of imidazodiazepine, are reported.