40648-96-2

Basic information

• Product Name: 1-Methyl-4-nitro-1H-imidazole-5-carbonitrile
• Synonyms: 1-Methyl-4-nitro-1H-imidazole-5-carbonitrile;1-methyl-4-nitroimidazole-5-carbonitrile
• CAS NO: 40648-96-2
• Molecular Formula: C₅H₄N₄O₂
• Molecular Weight: 152.1109
• Mol File: 40648-96-2.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 449.9 °C at 760 mmHg
• Flash Point: 225.9 °C
• Appearance: /
• Density: 1.5 g/cm³
• Vapor Pressure: 2.75E-08mmHg at 25°C
• Refractive Index: 1.661
• CAS DataBase Reference: 1-Methyl-4-nitro-1H-imidazole-5-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Methyl-4-nitro-1H-imidazole-5-carbonitrile(40648-96-2)
• EPA Substance Registry System: 1-Methyl-4-nitro-1H-imidazole-5-carbonitrile(40648-96-2)

Safety Data

• Hazardous Substances Data: 40648-96-2(Hazardous Substances Data)

Usage

General Description

1-Methyl-4-nitro-1H-imidazole-5-carbonitrile is a chemical compound with the molecular formula C6H5N3O2. It is a yellow crystalline solid that is used in the synthesis of pharmaceuticals and agrochemicals. 1-Methyl-4-nitro-1H-imidazole-5-carbonitrile is a nitroimidazole derivative, which has been studied for its potential use as an antiprotozoal and antibacterial agent. It is also used as an intermediate in the production of other organic compounds. However, it is important to handle this chemical with caution, as it is toxic and may cause irritation to skin, eyes, and respiratory system.

InChI:InChI=1/C5H4N4O2/c1-8-3-7-5(9(10)11)4(8)2-6/h3H,1H3

Upstream product

• 4897-25-0 5-chloro-1-methyl-4-nitroimidazole 
• 151-50-8 potassium cyanide 
• 4897-31-8 4-chloro-1-methyl-5-nitro-1H-imidazole 
• 933-87-9 1-methyl-5-bromo-4-nitro-1H-imidazole 
• 76529-47-0 4-Iodo-1-methyl-5-nitroimidazole 
• 64-17-5 ethanol 
• 68-12-2 N,N-dimethyl-formamide 
• 35681-63-1 5-Iodo-1-methyl-4-nitroimidazole 
• 13755-79-8 1-methyl-5-methylsulfonyl-4-nitroimidazole 
• 59177-47-8 4-bromo-1-methyl-5-nitro-1H-imidazole 

Downstream Products

• 40637-80-7 4-amino-5-cyano-1-methyl-1H-imidazole 
• 5413-88-7 5-Carboxamido-1-methyl-4-nitroimidazole 
• 54828-05-6 1-methyl-4-nitro-1H-imidazole-5-carboxylic acid 
• 71788-36-8 4-amino-1-methylimidazole-5-thiocarboxamide 
• 61982-14-7 1-methyl-4-nitroimidazolyl-5-carboxylic acid chloroanhydride 
• 929910-72-5 3-methyl-5-nitro-3H-imidazole-4-carboxylic acid (3,5-bis-trifluoromethyl-phenyl)-amide 
• 929910-71-4 3-methyl-5-nitro-3H-imidazole-4-carboxylic acid (3,4-bis-trifluoromethyl-phenyl)-amide 

Relevant articles and documents

AROMATIC DERIVATIVES, PREPARATION METHODS, AND MEDICAL USES THEREOF

The present disclosure relates generally to aromatic derivatives that are inhibitors of FGFR4 and are useful in treating FGFR4-associated diseases or conditions. Compositions containing the compounds of the present disclosure are also provided.

ortho-Substituted azoles as selective and dual inhibitors of VEGF receptors 1 and 2

We have developed a series of novel potent ortho-substituted azole derivatives active against kinases VEGFR-1 and VEGFR-2. Both specific and dual ATP-competitive inhibitors of VEGFR-2 were identified. Kinase activity and selectivity could be controlled by varying the arylamido substituents at the azole ring. The most specific molecule (17) displayed >10-fold selectivity for VEGFR-2 over VEGFR-1. Compound activities in enzymatic and cell-based assays were in the range of activities for reported clinical and development candidates (IC50 30 × 10-5 cm/min) is indicative of their potential for intestinal absorption upon oral administration.

Synthesis of 1-methyl-4-nitro-5-substituted-imidazole and substituted imidazolothiazole derivates as possible antiparasitic agents

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