54831-34-4Relevant academic research and scientific papers
CAMPHOR-DERIVED BETA-AMINO ALCOHOL COMPOUNDS, METHOD FOR MANUFACTURING THE SAME AND ASYMMETRIC ADDITION OF ORGANOZINC TO ALDEHYDES USING THE SAME
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Page/Page column 8, (2012/01/13)
A novel camphor-derived β-amino alcohol compound is disclosed. The novel camphor-derived β-amino alcohol compound can be used in asymmetric addition of organozinc to aromatic and aliphatic aldehydes, including linear aliphatic ones, thus generating corresponding secondary alcohols in high yields and enantiomeric excess.
Enantioselective diethylzinc addition to aldehydes using azetidine-derived chiral catalysts
Hermsen,Cremers,Thijs,Zwanenburg
, p. 4243 - 4245 (2007/10/03)
High levels of enantioselectivity have been achieved in the diethylzinc addition to both aromatic and aliphatic aldehydes, employing readily available N-substituted-azetidinyl(diphenylmethyl)methanols as chiral catalysts.
Catalytic enantioselective reactions. Part 18: Preparation of 3-deoxy-3-N,N-dialkylamino-1,2;5,6-di-O-isopropylidene-D-altritol derivatives from D-mannitol and their applications for catalytic enantioselective addition of dialkylzinc to aldehydes
Cho, Byung Tae,Chun, Yu Sung,Yang, Weon Ki
, p. 2149 - 2157 (2007/10/03)
A series of new chiral β-aminoalcohols, 3-deoxy-3-N,N-dialkylamino-1,2;5,6-di-O-isopropylidene-D-altritol derivatives 2-4 possessing a variety of amine substituents at the 3-position and thiol or acetylthio group at the 4-position was prepared from D-mannitol and enantioselective additions of diethylzinc to aldehydes using them as chiral catalysts were examined. Copyright (C) 2000 Elsevier Science Ltd.
Polymer-supported N-tritylaziridinyl(diphenyl)methanol as an effective catalyst in the enantioselective addition of diethylzinc to aldehydes
Ten Holte, Peter,Wijgergangs, Jan-Piet,Thijs, Lambertus,Zwanenburg, Binne
, p. 1095 - 1097 (2008/02/09)
(matrix presented) Novel polymer-supported N-tritylaziridino alcohol 2 was utilized as chiral ligand in the asymmetric addition of diethylzinc to aldehydes. High enantioselectivities were obtained for both aromatic and aliphatic aldehydes. The catalyst wa
Enantioselective addition of diethylzinc to aldehydes catalyzed by a new chiral β-amino alcohol derived from D-mannitol
Cho, Byung Tae,Chun, Yu Sung
, p. 1489 - 1492 (2007/10/03)
A new chiral β-dialkylamino alcohol 1 prepared from D-mannitol has been used as a highly effective chiral catalyst for the enantioselective addition of diethylzinc to unhindered aliphatic aldehydes to afford the product alcohols in up to 94% ee.
Enzymatic Preparation of Enantiomerically Pure Alkan-2- and -3-ols by Lipase Catalysed Hydrolysis with Pseudomonas cepacia in the Presence of Organic Media
Naoshima, Yoshinobu,Kamezawa, Makoto,Tachibana, Hojun,Munakata, Yoshihito,Fujita, Tomoki,et al.
, p. 557 - 562 (2007/10/02)
Pseudomonas cepacia lipase-catalysed hydrolysis of the acetates of racemic alkan-2- and -3-ols was carried out in the presence of organic media.Good to high enantioselectivity was observed in an acetone-water solvent system, the system leading to (R)-alcohols of 80-96percent ee.Enantioselectivity can be affected by the presence of the double bond in the unsaturated acetate prepared from an alkenol.The increased enantioselectivity observed for an acetone-water reaction system was utilized in the synthesis of optically active natural products possessing alkan-2-ol skeletons, such as (2R,6R,10R)-6,10,14-trimethyl pentadecan-2-ol, the natural form of the sex pheromone of Corcyra cephalonica, and (R)-sulcatol, an aggregation pheromone of ambrosia beetles.
