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Daphneolone is a natural product derived from the Daphne mezereum L. plant, known for its traditional use in folk medicine for anti-inflammatory and analgesic properties. It features a unique pentacyclic ring system and exhibits potent inhibitory activity against cyclooxygenase-2 (COX-2), an enzyme involved in the production of inflammatory prostaglandins. Daphneolone also demonstrates antiproliferative effects on cancer cells and has antimicrobial and antifungal activities, positioning it as a promising candidate for the development of novel therapeutic agents.

54835-64-2

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54835-64-2 Usage

Uses

Used in Pharmaceutical Industry:
Daphneolone is used as an anti-inflammatory agent for its ability to inhibit COX-2, reducing the production of inflammatory prostaglandins and providing relief from inflammation.
Used in Oncology:
Daphneolone is used as an anticancer agent due to its antiproliferative effects on cancer cells, showing potential as a lead compound for developing novel anti-inflammatory and anticancer treatments.
Used in Antimicrobial Applications:
Daphneolone is used as an antimicrobial agent, leveraging its natural ability to combat bacteria and contributing to the development of new therapeutic agents for infectious diseases.
Used in Antifungal Applications:
Daphneolone is used as an antifungal agent, harnessing its potential to fight fungal infections and aiding in the discovery of new treatments for various fungal conditions.

Check Digit Verification of cas no

The CAS Registry Mumber 54835-64-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,4,8,3 and 5 respectively; the second part has 2 digits, 6 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 54835-64:
(7*5)+(6*4)+(5*8)+(4*3)+(3*5)+(2*6)+(1*4)=142
142 % 10 = 2
So 54835-64-2 is a valid CAS Registry Number.

54835-64-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name (+/-)-daphneolone

1.2 Other means of identification

Product number -
Other names daphneolone

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:54835-64-2 SDS

54835-64-2Downstream Products

54835-64-2Relevant academic research and scientific papers

Syntheses of the (+/-)--Gingerols (Pungent Principles of Ginger) and Related Compounds through Regioselective Aldol Condensations: Relative Pungency Assays

Dennif, Phillip,Macleod, Ian,Whiting, Donald A.

, p. 82 - 87 (2007/10/02)

The deprotonation of trimethylsilylzingerone (13) by lithium di-isopropylamide at -78 deg C has been found to be regioselective (92 : 8 in favour of less-substituted enolate): the anion was condensed with alkanals and acyl imidazoles to give convenient syntheses of (+/-)--- and --gingerols (1) and -, -, and -gingerdiones (9).Similary, 3-methoxy-4-trimethylsilyloxybenzylideneacetone (17) gave the (+/-)---dehydrogingerols (8) and -, -, and -dehydrogingerdiones (10).The aldol reaction to -gingerol and methyl -gingerol was also conducted through a vinyloxyborane or through the enol silyl ether (TiCl4 catalysis).Results of organoleptic assays on these compounds are discussed, and the relation between pungency in the gingerols and in capsaicin is commented on.The aldol method was also used to synthesise the natural β-ketols(+/-)-daphneolone (25) and (+/-)-hexahydrocurcumin (4).

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