54835-64-2 Usage
General Description
Daphneolone is a natural product derived from the Daphne mezereum L. plant, which has been traditionally used in folk medicine for its anti-inflammatory and analgesic properties. The chemical structure of daphneolone consists of a unique pentacyclic ring system, and it exhibits potent inhibitory activity against cyclooxygenase-2 (COX-2), an enzyme responsible for the production of inflammatory prostaglandins. Daphneolone has also been found to possess antiproliferative effects on cancer cells, and it shows potential as a lead compound for the development of novel anti-inflammatory and anticancer agents. Additionally, daphneolone has been reported to have antimicrobial and antifungal activities, making it a promising candidate for the discovery of new therapeutic agents.
Check Digit Verification of cas no
The CAS Registry Mumber 54835-64-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,4,8,3 and 5 respectively; the second part has 2 digits, 6 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 54835-64:
(7*5)+(6*4)+(5*8)+(4*3)+(3*5)+(2*6)+(1*4)=142
142 % 10 = 2
So 54835-64-2 is a valid CAS Registry Number.
54835-64-2Relevant articles and documents
Syntheses of the (+/-)--Gingerols (Pungent Principles of Ginger) and Related Compounds through Regioselective Aldol Condensations: Relative Pungency Assays
Dennif, Phillip,Macleod, Ian,Whiting, Donald A.
, p. 82 - 87 (2007/10/02)
The deprotonation of trimethylsilylzingerone (13) by lithium di-isopropylamide at -78 deg C has been found to be regioselective (92 : 8 in favour of less-substituted enolate): the anion was condensed with alkanals and acyl imidazoles to give convenient syntheses of (+/-)--- and --gingerols (1) and -, -, and -gingerdiones (9).Similary, 3-methoxy-4-trimethylsilyloxybenzylideneacetone (17) gave the (+/-)---dehydrogingerols (8) and -, -, and -dehydrogingerdiones (10).The aldol reaction to -gingerol and methyl -gingerol was also conducted through a vinyloxyborane or through the enol silyl ether (TiCl4 catalysis).Results of organoleptic assays on these compounds are discussed, and the relation between pungency in the gingerols and in capsaicin is commented on.The aldol method was also used to synthesise the natural β-ketols(+/-)-daphneolone (25) and (+/-)-hexahydrocurcumin (4).
