18803-29-7Relevant academic research and scientific papers
Highly atom economical uncatalysed and I2-catalysed silylation of phenols, alcohols and carbohydrates, using HMDS under solvent-free reaction conditions (SFRC)
Jereb, Marjan
experimental part, p. 3861 - 3867 (2012/06/30)
An uncatalysed silylation of phenols, regardless on the aggregate state and nature of the substituents with 0.55 equiv of HMDS under solvent-free reaction conditions (SFRC) at room temperature is reported. Sterically hindered phenols, carbohydrates and most of the alcohols additionally required a catalytic amount (up to 2 mol %) of iodine. The reaction protocol is very simple; obtaining a pure product, particularly of uncatalysed reactions, was frequently a completely solvent-free process.
1,3-Dichloro-5,5-dimethylhydantoin (DCH) and trichloromelamine (TCM) as efficient catalysts for the chemoselective trimethylsilylation of hydroxyl group with 1,1,1,3,3,3-hexamethyldisilazane (HMDS) under mild conditions
Ghorbani-Choghamarani, Arash,Amani, Kamal,Zolfigol, Mohammad Ali,Hajjami, Maryam,Ayazi-Nasrabadi, Roia
experimental part, p. 255 - 260 (2009/12/06)
A highly convenient method for the trimethylsilylation of alcohols and phenols via treatment by hexamethyldisilazane in the presence of 1,3-dichloro-5,5-dimethylhydantoin (DCH) and/or trichloromelamine (TCM) as a catalyst has been developed. A wide variety of hydroxyl groups were selectively protected in CH2Cl2/CH3CN under mild conditions.
Trimethylsilylation of hydroxyl group with 1,1,1,3,3,3-hexamethyldisilazane (HMDS) catalyzed by tribromomelamine (TBM)
Ghorbani-Choghamarani, Arash,Zolfigol, Mohammad Ali,Hajjami, Maryam,Jafari, Shila
experimental part, p. 1208 - 1213 (2010/01/07)
Tribromomelamine (TBM) can be used as a novel catalyst for the trimethylsilylation of alcohols and phenols with 1,1,1,3,3,3- hexamethyldisilazane (HMDS). A wide variety of hydroxyl groups were selectively protected in CH2Cl2/CH3CN under mild conditions.
A mild and efficient method for chemoselective silylation of alcohols using hexamethyldisilazane in the presence of silica chloride
Shirini, Farhad,Zolfigol, Mohammad Ali,Mohammadi, Kamal
, p. 1567 - 1570 (2007/10/03)
Reaction of alcohols with hexamethyldisilazane in the presence of silica chloride provides efficiently the corresponding trimethylsilyl ethers. This system discriminates absolutely amines and thiols from alcohols.
Tungstophosphoric acid (H3PW12O40) as a heterogeneous inorganic catalyst. Activation of hexamethyldisilazane (HMDS) by tungstophosphoric acid for efficient and selective solvent-free O-silylation reactions
Firouzabadi, Habib,Iranpoor, Nasser,Amani, Kamal,Nowrouzi, Farhad
, p. 2601 - 2604 (2007/10/03)
The role of tungstophosphoric acid (H3PW12O40) as heterogeneous organic catalysts was discussed. Activation of hexamethyldisilazane by tungstophosphoric acid for efficient and selective solvent-free O-silylation reactions
Addition of trimethylsilyl cyanide to aromatic ketones promoted by organic solutions of lithium salts
Jenner, Gerard
, p. 491 - 494 (2007/10/03)
Cyanosilylation of aromatic ketones is strongly promoted in organic solutions of specific lithium salts (perchlorate and tetrafluoroborate). Acetonitrile solutions of LiBF4 are safe and efficient media for this reaction.
Bisphosphonic acid derivatives as anti-arthritic agents
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, (2008/06/13)
The bisphosphonates of formula (III) bicyclic bisphosphonates (V), and cyclic bisphosphonates (VII) are useful as anti-arthritic agents and do not have the side effects of anti-arthritic agents which are prostaglandin synthetase inhibitors.
Unusual Fragmentation of Trimethylsilylated Enols Derived from m- and p-Hydroxyacetophenones
Kraus, Rupert,Spiteller, Gerhard
, p. 861 - 865 (2007/10/02)
When 4-hydroxyacetophenone is treated with MSTFA the corresponding bis-trimethylsilylated enol ether (1a) is obtained.The mass spectrum of 1a is characterized by a M-1(1+) base peak.Extensive deuteration experiments revealed that the hydrogen is mainly
