54840-57-2Relevant articles and documents
Iron-Catalyzed Tertiary Alkylation of Terminal Alkynes with 1,3-Diesters via a Functionalized Alkyl Radical
Tian, Ming-Qing,Shen, Zhen-Yao,Zhao, Xuefei,Walsh, Patrick J.,Hu, Xu-Hong
supporting information, p. 9706 - 9711 (2021/03/19)
Direct oxidative C(sp)?H/C(sp3)?H cross-coupling offers an ideal and environmentally benign protocol for C(sp)?C(sp3) bond formations. As such, reactivity and site-selectivity with respect to C(sp3)?H bond cleavage have remained a persistent challenge. Herein is reported a simple method for iron-catalyzed/silver-mediated tertiary alkylation of terminal alkynes with readily available and versatile 1,3-dicarbonyl compounds. The reaction is suitable for an array of substrates and proceeds in a highly selective manner even employing alkanes containing other tertiary, benzylic, and C(sp3)?H bonds alpha to heteroatoms. Elaboration of the products enables the synthesis of a series of versatile building blocks. Control experiments implicate the in situ generation of a tertiary carbon-centered radical species.
Mechanistic Insights into the Radical S-adenosyl- l -methionine Enzyme NosL from a Substrate Analogue and the Shunt Products
Ji, Xinjian,Li, Yongzhen,Jia, Youli,Ding, Wei,Zhang, Qi
supporting information, p. 3334 - 3337 (2016/03/22)
The radical S-adenosyl-l-methionine (SAM) enzyme NosL catalyzes the transformation of l-tryptophan into 3-methyl-2-indolic acid (MIA), which is a key intermediate in the biosynthesis of a clinically interesting antibiotic nosiheptide. NosL catalysis was i
A five deuterium generation jasmonic, its salt, wherein the intermediate, preparation method and use
-
Paragraph 0127; 0128, (2017/04/03)
The invention discloses an 11,11,12,12,12-pentadeuterojasmonic acid disclosed as Formula 11, a salt and intermediate, and a preparation method and application thereof. The preparation method of the pentadeuterojasmonic acid comprises the following steps:
High-valent palladium-promoted formal Wagner-Meerwein rearrangement
Wu, Hongmiao,Yang, Bin,Zhu, Lin,Lu, Ronghua,Li, Guigen,Lu, Hongjian
, p. 5804 - 5807 (2016/11/29)
An oxy-palladation, formal Wagner-Meerwein rearrangement and fluorination cascade has been established for generating fluorinated oxazolidine-2,4-diones and oxazolidin-2-ones. The reaction has a broad substrate scope in which both aryl and alkyl groups can be utilized as efficient migrating groups. Experimental evidence suggests that the reaction is initiated by anti-oxy-palladation of the olefin, followed by oxidative generation of an alkyl PdIV intermediate and a concerted migration-fluorination.
CYCLOPROPYL MODULATORS OF P2Y12 RECEPTOR
-
Page/Page column 52, (2011/02/24)
The present invention relates to new cyclopropyl modulators of P2Y12 receptor activity, pharmaceutical compositions thereof, and methods of use thereof.
Phosphane-catalyzed [3+2] annulation of allenoates with aldehydes: A simple and efficient synthesis of 2-alkylidenetetrahydrofurans
Xu, Silong,Zhou, Lili,Ma, Renqin,Song, Haibin,He, Zhengjie
supporting information; scheme or table, p. 8698 - 8702 (2010/03/25)
A phosphane-catalyzed [3 +2] annulation of γ-methyl allenoates with aromatic aldehydes has been reported. This annulation provides a convergent and efficient synthesis of 2-alkylidenetetrahydrofurans, which are versatile synthetic building blocks for a vast array of 5-membered oxygenated heterocycle derivatives. The EIZ isomers of 2-(ethoxycarbonylmethylene) tetrahydrofurans, was separated by column chromatography on silica gel and their structural assignments were confirmed by H and C NMR spectroscopy data and X-ray crystallographic analysis. The nature of the substituent, as well as the reaction conditions, has a significant influence on the reactivity patterns of γ-substituted allenoates with aldehydes. The phosphorus ylide, generated from the phosphonium dienolate 8 by an overall 1,4-hydrogen shift, is believed to be the key intermediate responsible for the [3 + 2] annulation and other transformations of γ-methyl allenoates with aldehydes.
An improved procedure for the synthesis of labelled fatty acids utilizing diethyl malonate
Kasumov, Takhar,Brunengraber, Henri
, p. 171 - 176 (2007/10/03)
An improved procedure for the preparation and purification of labeled fatty acids by malonic ester synthesis has been developed. This method uses the different hydrolysis rates of the monoalkylmalonic ester intermediate and its dialkylmalonic ester side p
Deuterated analogues of 4,8-dimethyldecanal, the aggregation pheromone of Tribolium castaneum: Synthesis and pheromonal activity
Kim, Junheon,Matsuyama, Shigeru,Suzuki, Takahisa
, p. 921 - 934 (2007/10/03)
To elucidate the deuterium isotope effect (DIE) in pheromonal activity and to investigate the biosynthetic pathway of 4,8-dimethyldecanal (4,8-DMD; 1), the aggregation pheromone of the red flour beetle (Tribolium castaneum), deuterated analogues of 4,8-DMDs (2, 3, 4, and 5), were synthesized and their pheromonal activities were tested using a two-hole pitfall olfactometer. Although no apparent DIE was observed in their pheromonal activities, 4,8-DMD-1-d 1 (2) was less attractive than other analogues, which suggested that the bond distance between the formyl group of 1 and its receptor was critical in pheromone recognition by T. castaneum. Copyright 2004 John Wiley & Sons, Ltd.
Complete stereochemistry of tetrafibricin
Kobayashi, Yoshihisa,Czechtizky, Werngard,Kishi, Yoshito
, p. 93 - 96 (2007/10/03)
(Matrix presented) With use of the NMR databases in achiral and chiral solvents, the complete stereochemistry of tetrafibricin (1) has been elucidated without degradation of the carbon framework.
