54840-97-0

Upstream product

• 27895-67-6 N-(3,4-dimethoxybenzylidene)aniline 
• 151-50-8 potassium cyanide 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 62-53-3 aniline 
• 143-33-9 sodium cyanide 
• 7677-24-9 trimethylsilyl cyanide 

Downstream Products

• 75638-42-5 (3,4-Dimethoxy-phenyl)-phenylamino-acetic acid; hydrochloride 
• 1381802-47-6 4-amino-5-(3,4-dimethoxyphenyl)-1,3-diphenyl-1H-pyrrol-2(5H)-one 
• 1381803-69-5 C₂₄H₂₂N₂O₃ 
• 72867-66-4 N-[1-Cyano-1-(3,4-dimethoxy-phenyl)-2-phenyl-ethyl]-N-phenyl-benzamide 
• 3141-93-3 4',5'-dimethoxydeoxybenzoin 

Relevant academic research and scientific papers

Lithium tetrafluoroborate-catalyzed solventless synthesis of α-aminonitriles

Lithium tetrafluoroborate-catalyzed one-pot, highly efficient, and solvent-free protocol has been developed for the synthesis of α-aminonitriles from aldehydes/ketones, amines, and trimethylsilyl cyanide.

Phosphine-Catalyzed Sequential Michael Addition between α-Aminonitriles and Methyl Acrylate for Cyclization: Synthesis of N-Aryl-Substituted Pyrrolidines

Abstract: N-Aryl-substituted pyrrolidine derivativeswere synthesized via tributylphosphine-catalyzed sequential Michael addition ofα-aminonitriles and methyl acrylate as starting materials. The first Michaeladdition between α-aminonitrile and methyl acryl

Role of (3-aminopropyl)tri alkoxysilanes in grafting of chlorosulphonic acid immobilized magnetic nanoparticles and their application as heterogeneous catalysts for the green synthesis of α-aminonitriles

The surface modification of SiO2 coated Fe3O4 nanoparticles by grafting silane coupling agents is a highly significant approach to enhancing the interface interaction between the inorganic magnetic core and the organic fun

Approaches to the construction of substituted 4-amino-1 H -pyrrol-2(5 H)-ones

Fully substituted 4-aminopyrrolones are easily accessed via simple routes starting from imines, ketones, or α-bromophenyl acetonitriles. Imines were reacted with KCN/NH4Cl in aqueous ethanol to produce α-arylamino benzyl cyanides. On the other hand, ketones were transformed to the desired α-amino nitriles using a modified Strecker reaction. Then, α-amino nitrile precursors were allowed to react with a suitable acyl halide to produce the corresponding amides. Further treatment of these amides with ethanolic KOH converted them to highly substituted 4-amino-1H-pyrrol-2(5H)- one derivatives in moderate to excellent yields.

Ga-TUD-1: A new heterogeneous mesoporous catalyst for the solventless expeditious synthesis of α-aminonitriles

The high surface area three-dimensional porous catalyst has been prepared and characterized by TEM, BET S.A, low angle XRD, 29Si MAS NMR, NH3 TPD techniques. A simple, efficient and rapid method for the green synthesis of α-aminonitriles has been demonstrated over a new mesoporous gallosilicate catalyst Ga-TUD-1. The solventless technique has been applied for the synthesis of a range of compounds with variable functionality with excellent yield and selectivity. The catalyst has been recycled four times with reproducible yield.

K2PdCl4 catalyzed efficient multicomponent synthesis of α-aminonitriles in aqueous media

An efficient, mild and environmentally friendly method has been developed for the Strecker reaction to synthesize α-aminonitriles in the presence of K2PdCl4 as a catalyst. The three-component one-pot condensation of an aldehyde, amine and trimethylsilyl cyanide proceeded smoothly in water to afford the corresponding product in high yield with short reaction times. Crown Copyright

One-pot three-component synthesis of α-amino nitriles catalyzed by 2,4,6-trichloro-1,3,5-triazine (cyanuric acid)

A simple and efficient method has been developed for the synthesis of α-amino nitriles from aldehydes, amines and trimethylsilyl cyanide (Me3SiCN) in the presence of a catalytic amount of cyanuric acid at room temperature.

Synthetic Uses of Open-Chain Analogues of Reissert Compounds

Open-chain analogues, 2, of Reissert compounds are readily obtained by reaction of cyanohydrins with primary amines, the resulting aminonitriles, 1, then being acylated.Hydrofluoroborate salts, 3, of 2 are prepared by reaction with fluoroboric acid in glacial acetic acid.The salts, 3, undergo 1,3-dipolar addition reactions with reactive alkynes to give substituted pyrroles and with ethyl acrylate to give a different type of substituted pyrrole, the initial step in this instance being a Diels-Alder reaction.The open-chain Reissert analogues 2 also undergo base-catalyzed reactions, such as alkylation to provide compounds 22, which, in turn, undergo cleavage reactions in ethanolic alkali to give ketones 23.A conjugate addition reaction of the anion 18 to methyl acrylate to give, after some subsequent steps, a substituted pyrrole, 9, has also been demonstrated. α-Anilino ketones 27 result when the anion 18 is caused to react with aldehydes, the initial reaction mixtures being subjected to subsequent alkaline hydrolysis.Finally, N-benzyl Reissert analogues have been found to give desoxybenzoins plus benzonitriles on treatment with sodium hydride in tetrahydrofuran.

A Novel Synthesis of N-Substituted Amino Acids

Addition of hydrocyanic acid to schiff bases has led to a method for the synthesis of N-substituted amino acid hydrochlorides in excellent yield (ca. 90percent).

α-Amino substituted thioacetamides

The invention relates to thioamides of formula I SPC1 and acid addition salts thereof wherein R1 and R2 are selected from the group consisting of hydrogen, lower alkyl, and phenyl and R3 and R 4 are selected fro