548437-52-1Relevant academic research and scientific papers
Synthesis and Preliminary Biological Evaluation of 6-O-[11C]-[(methoxymethyl)benzyl]guanines, New Potential PET Breast Cancer Imaging Agents for the DNA Pepair Protein AGT
Liu, Xuan,Zheng, Qi-Huang,Fei, Xiangshu,Wang, Ji-Quan,Ohannesian, David W.,Erickson, Leonard C.,Stone, K. Lee,Hutchins, Gary D.
, p. 641 - 644 (2003)
Novel radiolabeled O6-benzylguanine derivatives, 6-O-[11C]-[(methoxymethyl)benzyl]guanines ([11C]p-O6-MMBG, 1a; [11C]m-O6-MMBG, 1b; ([11C]o-O6-MMBG, 1c), have been synthesized for evaluation as new potential positron emission tomography (PET) breast cancer imaging agents for DNA repair protein, O6-alkylguanine-DNA alkyltransferase (AGT).
A convenient procedure for the synthesis of O6-benzylguanine derivatives by phase transfer catalysis
Liu, Xuan,Zheng, Qi-Huang,Hutchins, Gary D.,Fei, Xiangshu,Erickson, Leonard C.,Miller, Kathy D.,Mock, Bruce H.,Glick-Wilson, Barbara E.,Winkle, Wendy L.,Stone, K. Lee,Carlson, Kathy A.
, p. 941 - 952 (2007/10/03)
A convenient procedure by phase transfer catalysis has been developed for the synthesis of O6-BG (1) and its derivatives hydroxymethyl-BG (2a-c), halo-BG (3a-c, 4a-c, 5a-c, 6a-c), methoxy-BG (7), and methyl-BG (8). Compounds 2b, 2c, 4b, 4c, 5b, 5c, 6a, and 6c are new compounds.
