54851-35-3

Usage

Uses

Used in Pharmaceutical Research:
5-amino-6-chloro-1H-pyrimidine-4-thione is used as a key intermediate in the synthesis of various pharmaceutical compounds for its potential antiviral and antitumor properties. Its unique structure allows for the development of drugs that can target specific viral and cancerous cells, offering new therapeutic options.
Used in Organic Synthesis:
In the field of organic synthesis, 5-amino-6-chloro-1H-pyrimidine-4-thione serves as a valuable building block. Its versatile structure can be modified to create a range of new compounds with tailored properties for specific applications, making it an essential component in the development of novel organic materials.
Used in Medicinal Chemistry:
5-amino-6-chloro-1H-pyrimidine-4-thione is utilized as a starting material in the design and synthesis of new drugs in medicinal chemistry. Its unique combination of functional groups allows for the creation of compounds with enhanced biological activity and selectivity, contributing to the advancement of drug discovery and development.
Used in Antiviral Applications:
5-amino-6-chloro-1H-pyrimidine-4-thione is employed as an antiviral agent, leveraging its ability to inhibit viral replication and reduce the severity of viral infections. Its potential in this area makes it a promising candidate for the development of new antiviral therapies.
Used in Antitumor Applications:
In the realm of antitumor research, 5-amino-6-chloro-1H-pyrimidine-4-thione is used for its potential to inhibit tumor growth and proliferation. Its unique structure allows for the development of compounds that can target cancer cells specifically, offering new avenues for cancer treatment and management.

InChI:InChI=1/C4H4ClN3S/c5-3-2(6)4(9)8-1-7-3/h1H,6H2,(H,7,8,9)

Upstream product

• 5413-85-4 5-amino-4,6-dichloropyridimine 

Downstream Products

• 57417-53-5 5-amino-3H-pyrimidine-4-thione 
• 54660-78-5 5-amino-4-chloropyrimidine 
• 32605-32-6 4-chloro-6-(4-nitro-phenyl)-6,7-dihydro-5H-pyrimido[4,5-b][1,4]thiazin-6-ol 
• 13316-12-6 7-chloro[1,3]thiazolo[5,4-d]pyrimidine 
• 19084-50-5 4-chloro-6-phenyl-7H-pyrimido[4,5-b][1,4]thiazine 
• 19084-41-4 4-chloro-6-(2,5-dichloro-phenyl)-6,7-dihydro-5H-pyrimido[4,5-b][1,4]thiazin-6-ol 
• 19084-49-2 6-(4-bromo-phenyl)-4-chloro-7H-pyrimido[4,5-b][1,4]thiazine 

Relevant academic research and scientific papers

FERROPORTIN INHIBITORS AND METHODS OF USE

The subject matter described herein is directed to Ferroportin inhibitor compounds of Formula I and pharmaceutical salts thereof, methods of preparing the compounds, pharmaceutical compositions comprising the compounds and methods of administering the compounds for prophylaxis and/or treatment of diseases caused by a lack of hepcidin or iron metabolism disorders, particularly iron overload states, such as thalassemia, sickle cell disease and hemochromatosis.

BIARYL KINASE INHIBITORS

The present disclosure is directed to biaryl compounds of formula (I) which can inhibit AAKl (adaptor associated kinase 1), compositions comprising such compounds and their use for treating e.g. pain, Alzheimer's disease, Parkinson's disease and schizophrenia.

PIPERIDINE SUBSTITUTED PYRAZOLO[1,5-A]PYRIMIDINE DERIVATIVES WITH INHIBITORY ACTIVITY ON THE REPLICATION OF THE RESPIRATORY SYNCYTIAL VIRUS (RSV)

The invention concerns novel substituted bicyclic pyrazolo pyrimidine compounds of formula (I) having antiviral activity, in particular, having an inhibitory activity on the replication of the respiratory syncytial virus (RSV). The invention further conce

IRAK INHIBITORS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same.

HETEROCYCLIC COMPOUNDS AND USES THEREOF

Compounds and pharmaceutical compositions of formulae (I), (XI) and (XII) as PI3 kinase modulators and their use in the treatment of diseases such as cancer.

HETEROCYCLIC COMPOUNDS AND USES THEREOF

Compounds and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including PI3 kinase activity, are described herein.

THERAPEUTIC AGENTS

The invention provides a compound of formula (I): wherein R1, and W have any of the values defined in the application; or a salt thereof. The compounds and salts thereof have beneficial therapeutic properties (e.g. immunosuppressant properties).

N-ARYL-ISOXAZOLOPYRIMIDIN-4-AMINES AND RELATED COMPOUNDS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS AND THE USE THEREOF

Disclosed are N-aryl-isoxazolopyrimidin-4-amines and related compounds thereof, represented by the Formula (I): wherein Ar, R1-R5, A, B, D, E, F and H are defined herein. The present invention relates to the discovery that compounds having Formula I are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention may be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.

PREPARATION OF POLYMER CONJUGATES OF THERAPEUTIC, AGRICULTURAL, AND FOOD ADDITIVE COMPOUNDS

Disclosed is a process for preparing polymer conjugates of agricultural, therapeutic, and food additive compounds using Mitsunobu conditions.

Multimeric VLA-4 antagonists comprising polymer moieties

Disclosed are conjugates which bind VLA-4. Certain of these conjugates also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such conjugates are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The conjugates can also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis.