54874-97-4Relevant articles and documents
Synthesis and SAR of novel 4,5-diarylimidazolines as potent P2X7 receptor antagonists
Merriman, Gregory H.,Ma, Liang,Shum, Patrick,McGarry, Daniel,Volz, Frank,Sabol, Jeffrey S.,Gross, Alexandre,Zhao, Zhicheng,Rampe, David,Wang, Lin,Wirtz-Brugger, Friederike,Harris, Bruce A.,Macdonald, Douglas
, p. 435 - 438 (2005)
The synthesis and SAR of a series of potent P2X7 receptor antagonists is described. The synthesis featured high-throughput solution- and solid-phase techniques including a microwave induced imidazoline formation. A series of 4,5-diarylimidazoline libraries were prepared using high-throughput solid-phase and microwave techniques. The compounds were evaluated as P2X 7 antagonists and their SAR is described.
