548776-04-1

Basic information

• Product Name: 1-(4,5-dichloro-2-nitro-phenyl)-4-trimethylsilanyl-but-3-yn-2-one
• Synonyms: 1-(4,5-dichloro-2-nitro-phenyl)-4-trimethylsilanyl-but-3-yn-2-one
• CAS NO: 548776-04-1
• Molecular Weight: 330.243
• Mol File: 548776-04-1.mol

Chemical Properties

• CAS DataBase Reference: 1-(4,5-dichloro-2-nitro-phenyl)-4-trimethylsilanyl-but-3-yn-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4,5-dichloro-2-nitro-phenyl)-4-trimethylsilanyl-but-3-yn-2-one(548776-04-1)
• EPA Substance Registry System: 1-(4,5-dichloro-2-nitro-phenyl)-4-trimethylsilanyl-but-3-yn-2-one(548776-04-1)

Safety Data

• Hazardous Substances Data: 548776-04-1(Hazardous Substances Data)

Upstream product

• 14630-40-1 Bis(trimethylsilyl)ethyne 
• 37777-90-5 2-nitro-4,5-dichlorophenylacetic acid 
• 5807-30-7 3,4-dichlorophenyl acetic acid 

Downstream Products

• 548776-05-2 (E)-1-(4,5-Dichloro-2-nitro-phenyl)-4-iodo-but-3-en-2-one 
• 548776-09-6 1-(4,5-dichloro-2-nitro-phenyl)-but-3-yn-2-one 

Relevant articles and documents

Towards the synthesis of osteoclast inhibitor SB-242784

Osteoclast inhibitor SB-242784 (1) was prepared from pivotal indol intermediate 4. A 'Stille' cross coupling of organotin 2c with bromo acrylate 11 afforded diene 12 which was also obtained via a reduction-isomerization process of enyne 16. Bromoamide 3 was prepared from the corresponding acid 7 which was readily obtained from bromopyruvic acid.