548797-52-0Relevant articles and documents
Synthesis and SAR studies of 3,6-disubstituted indazole derivatives as potent hepcidin production inhibitors
Fukuda, Takeshi,Ueda, Kenjiro,Ishiyama, Takashi,Goto, Riki,Muramatsu, Sumie,Hashimoto, Masami,Watanabe, Kengo,Tanaka, Naoki
, p. 2148 - 2152 (2017/04/27)
Hepcidin has emerged as the central regulatory molecule of systemic iron homeostasis. Inhibition of hepcidin could be a strategy favorable to treating anemia of chronic disease (ACD). We report herein the synthesis and structure-activity relationships (SARs) of a series of indazole compounds as hepcidin production inhibitors. The optimization study of compound 1 led to a potent hepcidin production inhibitor 45, which showed serum hepcidin lowering effects in a mouse IL-6 induced acute inflammatory model.
6-Heteroaryl-pyrazolo[3,4-b]pyridines: Potent and selective inhibitors of Glycogen Synthase Kinase-3 (GSK-3)
Witherington, Jason,Bordas, Vincent,Gaiba, Alessandra,Naylor, Antoinette,Rawlings, Anthony D.,Slingsby, Brian P.,Smith, David G.,Takle, Andrew K.,Ward, Robert W.
, p. 3059 - 3062 (2007/10/03)
A series of 6-heteroaryl-pyrazolo[3,4-b]pyridines has been optimised to afford potent inhibitors of Glycogen Synthase Kinase-3 (GSK-3). These analogues display excellent selectivity over the closely related Cyclin Dependant Kinase-2 (CDK-2).