548798-17-0Relevant academic research and scientific papers
New synthesis of pyrvinium that inhibits the β-catenin/Tcf4 pathway
Mao, Yongjun,Lin, Nan,Tian, Wang,Huang, Ziwei,An, Jing
, p. 1179 - 1185 (2012)
A new and converged route is described for synthesis of pyrvinium, an anthelmintic and antitumor agent. This method uses easily obtained materials and simple and practical reactions, including the key Friedlaender condensation, to form the quinoline ring. The final product is generated through eight steps, with 23% yield and 96.6% purity (HPLC). This synthetic pyrvinium effectively inhibits β-catenin/Tcf4 driven TOP-luciferase activity, with an IC50 value 50 of 0.54 ± 0.06 μM.
