13796-06-0

Basic information

• Product Name: 2-Nitro-5-chlorobenzaldehyde dimethyl acetal
• Synonyms: 2-Nitro-5-chlorobenzaldehyde dimethyl acetal;4-Chloro-2-(dimethoxymethyl)-1-nitrobenzene;5-Chloro-2-nitrobenzaldehyde dimethyl acetal
• CAS NO: 13796-06-0
• Molecular Formula: C₉H₁₀ClNO₄
• Molecular Weight: 0
• Mol File: 13796-06-0.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Nitro-5-chlorobenzaldehyde dimethyl acetal(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Nitro-5-chlorobenzaldehyde dimethyl acetal(13796-06-0)
• EPA Substance Registry System: 2-Nitro-5-chlorobenzaldehyde dimethyl acetal(13796-06-0)

Safety Data

• Hazardous Substances Data: 13796-06-0(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 6628-86-0 5-chloro-2-nitrobenzaldehyde 
• 149-73-5 trimethyl orthoformate 

Downstream Products

• 1184030-26-9 (3-dimethoxymethyl-4-nitro-phenyl)-morpholin-4-yl-phenyl-acetonitrile 
• 20423-24-9 2-amino-5-(dimethylamino)benzaldehyde 
• 1071778-66-9 N,N-dimethyl-2-[2-(2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl)ethenyl]-6-quinolinamine 
• 7187-62-4 6-(dimethylamino)-2-[2-(2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl)ethenyl]-1-methyl-quinolinium 
• 548798-17-0 3-(dimethoxymethyl)-N,N-dimethyl-4-nitrobenzenamine 
• 548798-20-5 2-(dimethoxymethyl)-1-nitro-4-phenoxy-benzene 
• 155626-37-2 5-(4-hydroxypiperidino)-2-nitrobenzaldehyde dimethylacetal 
• 119198-32-2 6-<4-(3,4-dimethoxybenzoyl)-1-piperazinyl>-1H,3H-quinazoline-2,4-dione hydrochloride 
• 119198-28-6 6-<4-(3,4-dimethoxybenzoyl)-1-piperazinyl>-1,4-dihydro-2H-3,1-benzoxazin-2-one hydrochloride 
• 119198-36-6 6-<4-(3,4-dimethoxybenzoyl)-1-piperazinyl>-1,3-dimethyl-1H,3H-quinazoline-2,4-dione 
• 119198-39-9 6-<4-(3,4-dimethoxybenzoyl)-1-piperazinyl>3,4-dihydro-1H-2,1,3-benzothiadiazine-2,2-dioxide 
• 119198-35-5 6-<4-(3,4-dimethoxybenzoyl)-1-piperazinyl>-3-methyl-1H,3H-quinazoline-2,4-dione 
• 119198-41-3 6-<4-(3,4-dimethoxybenzoyl)-1-piperazinyl>-3,4-dihydro-3-methyl-1H-quinazoline-2-thione 
• 119198-40-2 6-[4-(3,4-Dimethoxy-benzoyl)-piperazin-1-yl]-3-methyl-3,4-dihydro-1H-quinazolin-2-one 

Relevant articles and documents

New synthesis of pyrvinium that inhibits the β-catenin/Tcf4 pathway

A new and converged route is described for synthesis of pyrvinium, an anthelmintic and antitumor agent. This method uses easily obtained materials and simple and practical reactions, including the key Friedlaender condensation, to form the quinoline ring. The final product is generated through eight steps, with 23% yield and 96.6% purity (HPLC). This synthetic pyrvinium effectively inhibits β-catenin/Tcf4 driven TOP-luciferase activity, with an IC50 value 50 of 0.54 ± 0.06 μM.

NOVEL 2-AMINO-QUINAZOLINE DERIVATIVES USEFUL AS INHIBITORS OF β-SECRETASE (BACE)

The present invention is directed to novel 2-amino-3, 4-dihydro-quinazoline derivatives, pharmaceutical compositions containing them and their use in the treatment of Alzheimer's disease (AD) and related disorders. The compounds of the invention are inhibitors of P-secretase, also known as n-site cleaving enzyme and BACE.

2-AMINO-QUINAZOLINE DERIVATIVES USEFUL AS INHIBITORS OF B-SECRETASE (BACE)

The present invention is directed to novel 2-amino-3,4-dihydro-quinazoline derivatives, pharmaceutical compositions containing them and their use in the treatment of Alzheimer's disease (AD) and related disorders. The compounds of the invention are inhibi