5488-51-7

Usage

Uses

Used in Pharmaceutical Industry:
Δ^5,7-Pregnen-3,20-diethylenketal is used as an intermediate in the synthesis of Dydrogesterone (D826000), a synthetic progestin. It plays a crucial role in the development of hormone therapy medications, which are widely used for treating various hormonal imbalances and conditions related to the reproductive system.
Used in Hormone Therapy:
Δ^5,7-Pregnen-3,20-diethylenketal is used as a precursor for the production of Dydrogesterone, which is largely employed in hormone therapy. This therapy is essential for managing conditions such as menstrual disorders, menopausal symptoms, and hormone-related contraceptives. Δ^5,7-Pregnen-3,20-diethylenketal's role in the synthesis of Dydrogesterone highlights its importance in the pharmaceutical industry for developing effective hormone therapy medications.

Upstream product

• 57-83-0 Progesterone 
• 7093-55-2 5-pregnene-3,20-dione-3,20-bisethyleneketal 
• 74496-89-2 7α-bromo-5-pregnene-3,20-dione-3,20-bisethyleneketal 
• 32164-74-2 9α,10β-dehydroprogesterone diethylene ketal 

Relevant academic research and scientific papers

Preparation method of dydrogesterone intermediate

The invention discloses a preparation method of a dydrogesterone intermediate. The preparation method is characterized by comprising the following steps: dissolving 5,7-diene steroid compound in an organic solvent to obtain a solution as a raw material; and carrying out a photocatalytic reaction and separating to obtain the dydrogesterone intermediate, wherein the 5,7-diene steroid compound is 7-dehydropregnenolone acetate, pregna-5,7-diene-3,20-diketodivinyl ketal, 7-dehydropregnenolone, ergosterol or pregna-5,7-diene-3,20-diketo-3-vinyl ketal, and a lamp used in the photocatalytic reaction comprises an LED ultraviolet lamp with the wavelength range of 295-335 nm. The preparation method of the dydrogesterone intermediate is high in yield, low in cost, safer in preparation and friendlier to environment.

Production process capable of industrially synthesizing dydrogesterone

The invention discloses a production process capable of industrially synthesizing dydrogesterone. Easily available progesterone is used as a raw material, and dydrogesterone is prepared through the steps of carbonyl protection, bromination, debromination, photochemical ring-opening reaction, photochemical ring-closing reaction, deprotection and double bond isomerization. The production process hasthe advantages of easily available initial raw materials, and easiness in implementation of each step and higher yield; the production process is simple and convenient to operate, is green and environment-friendly, and can be easily amplified to industrial production.