54898-80-5Relevant academic research and scientific papers
The rapid generation of isothiocyanates in flow
Baumann, Marcus,Baxendale, Ian R.
, p. 1613 - 1619 (2013)
Isothiocyanates are versatile starting materials for a wide range of chemical reactions. However, their high nucleophilic susceptibility means they are best prepared and used immediately. We report here on a flow platform for the fast and efficient formation of isothiocyanates by the direct conversion of easily prepared chloroximes. To expedite this chemistry a flow insert cartridge containing two immobilised reagents is used to affect the chemical transformation which typically eliminates the requirements for any conventional work-up or purification of the reaction stream.
