54903-57-0

Basic information

• Product Name: 1-[3-hydroxy-4-(methylamino)phenyl]ethanone
• Synonyms: 1-[3-Hydroxy-4-(methylamino)phenyl]ethanone
• CAS NO: 54903-57-0
• Molecular Formula: C₉H₁₁NO₂
• Molecular Weight: 165.1891
• Mol File: 54903-57-0.mol

Chemical Properties

• Melting Point: 169–170°C
• Boiling Point: 342°C at 760 mmHg
• Flash Point: 160.6°C
• Density: 1.189g/cm³
• Vapor Pressure: 3.91E-05mmHg at 25°C
• Refractive Index: 1.604
• CAS DataBase Reference: 1-[3-hydroxy-4-(methylamino)phenyl]ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[3-hydroxy-4-(methylamino)phenyl]ethanone(54903-57-0)
• EPA Substance Registry System: 1-[3-hydroxy-4-(methylamino)phenyl]ethanone(54903-57-0)

Safety Data

• Hazardous Substances Data: 54903-57-0(Hazardous Substances Data)

Usage

Preparation

Preparation from 6-acetyl-3-methylbenzoxazolinone by alkaline hydrolysis with boiling 10% aqueous sodium hydroxide solution (90–100%).

Upstream product

• 54903-61-6 6-acetyl-3-methylbenzoxazolinone 
• 21892-80-8 3-methylbenzo[d]oxazol-2(3H)-one 

Downstream Products

• 116337-69-0 7-Acetyl-2,4-dimethyl-4H-benzo[1,4]oxazin-3-one 
• 136629-00-0 7-(4-morpholino-2-methylenepropionyl)-2,4 dimethyl-2,3-dihydrobenzoxazin-<1,4>-3-one hydrochloride 
• 123172-63-4 7-[(E)-3-(4-Hydroxy-phenyl)-acryloyl]-2,4-dimethyl-4H-benzo[1,4]oxazin-3-one 
• 123172-60-1 7-[(E)-3-(4-Chloro-phenyl)-acryloyl]-2,4-dimethyl-4H-benzo[1,4]oxazin-3-one 
• 123172-64-5 7-[(E)-3-(4-Hydroxy-phenyl)-acryloyl]-2,2,4-trimethyl-4H-benzo[1,4]oxazin-3-one 
• 123172-61-2 7-[(E)-3-(4-Chloro-phenyl)-acryloyl]-2,2,4-trimethyl-4H-benzo[1,4]oxazin-3-one 
• 116363-85-0 7-[(E)-3-(4-Hydroxy-phenyl)-acryloyl]-4-methyl-4H-benzo[1,4]oxazin-3-one 
• 116337-84-9 7-[(E)-3-(4-Chloro-phenyl)-acryloyl]-4-methyl-4H-benzo[1,4]oxazin-3-one 
• 123172-57-6 2,4-Dimethyl-7-[(E)-(3-phenyl-acryloyl)]-4H-benzo[1,4]oxazin-3-one 
• 116337-85-0 4-Methyl-7-[(E)-(3-phenyl-acryloyl)]-4H-benzo[1,4]oxazin-3-one 
• 123172-58-7 2,2,4-Trimethyl-7-[(E)-(3-phenyl-acryloyl)]-4H-benzo[1,4]oxazin-3-one 
• 6832-88-8 methoxy-2 nitro-4 N-methylaniline 
• 887473-62-3 1-(3-methoxy-4-(methylamino)phenyl)ethanone 
• 116337-71-4 7-Acetyl-4-methyl-4H-benzo[1,4]oxazin-3-one 

Relevant articles and documents

Acyl-7 dihydro-2,3 benzoxazin-1,4 ones-3 et proprietes normolipemiantes

7-Acyl-2,3-dihydro-1,4-benzoxazin-3-ones and normolipemic properties.Fibrates are still among the most widely used drugs for the treatment of dyslipoproteinemia. 7-Acyl-2,3-dihydro-1,4-benzoxazin-3-ones (Fig.1B) can be considered as conformationally restrained analogues of fibrates, such as fenofibrate.These compounds have been prepared and studied for their normolipemic activity particularly on plasma cholesterol, triglyceride and high density lipoprotein (HDL) cholesterol levels.Hepatotoxicity and mutagenicity have also been evaluated.Some of them show an interesting activity, quite comparable to fenofibrate, and are devoid of hepatotoxicity. hyperlipidemia / hypocholesterolemic drugs / fibrates / 7-acyl-1,4-benzoxazin-3-ones

6 Acylbenzoxazolinone derivatives. II. Preparation of some transformation products

Some transformation products of acylbenzoxazolinones (aminophenols, alcohols, and chalcone derivatives) are described. Preliminary pharmacodynamic study showed analgesic activity.