54903-66-1

Usage

Uses

Used in Organic Synthesis:
3-Methyl-2-oxo-2,3-dihydro-1,3-benzoxazole-6-carboxaldehyde, 97% is used as a synthetic intermediate for the preparation of complex organic molecules. Its unique structure and functional groups facilitate versatile reactions, making it a valuable component in the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 3-Methyl-2-oxo-2,3-dihydro-1,3-benzoxazole-6-carboxaldehyde, 97% serves as a crucial building block for the development of novel therapeutic agents. Its incorporation into drug candidates can potentially enhance their pharmacological properties, such as potency, selectivity, and bioavailability.
Used in Pharmaceutical Development:
3-Methyl-2-oxo-2,3-dihydro-1,3-benzoxazole-6-carboxaldehyde, 97% is used as a key component in the design and synthesis of new pharmaceuticals. Its presence in drug molecules can contribute to improved therapeutic effects and reduced side effects, making it an essential tool in drug discovery and development.
Used in Agrochemicals:
In the agrochemical industry, 3-Methyl-2-oxo-2,3-dihydro-1,3-benzoxazole-6-carboxaldehyde, 97% is utilized as a starting material for the synthesis of bioactive compounds with pesticidal properties. Its incorporation into agrochemical products can lead to the development of more effective and environmentally friendly solutions for crop protection.
Used in Materials Science:
3-Methyl-2-oxo-2,3-dihydro-1,3-benzoxazole-6-carboxaldehyde, 97% also finds applications in materials science, where it can be used to develop new materials with unique properties. Its potential use in the synthesis of advanced polymers, coatings, and other materials can contribute to the development of innovative products with improved performance characteristics.

InChI:InChI=1/C9H7NO3/c1-10-7-3-2-6(5-11)4-8(7)13-9(10)12/h2-5H,1H3

Upstream product

• 21892-80-8 3-methylbenzo[d]oxazol-2(3H)-one 
• 100-97-0 hexamethylenetetramine 
• 59-49-4 2-Benzoxazolinone 

Downstream Products

• 54903-56-9 3-hydroxy-4-methylaminobenzaldehyde 
• 80427-96-9 3-(3-methyl-6-benzoxazolinonyl)acrylophenone 
• 1255313-40-6 6-[1-hydroxy-2-(4-nitrophenyl)ethyl]-3-methylbenzo[d]oxazol-2(3H)-one 
• 1255313-41-7 6-[1-hydroxy-2-(2-nitrophenyl)ethyl]-3-methylbenzo[d]oxazol-2(3H)-one 

Relevant academic research and scientific papers

Substituted Pyran Derivatives

Certain 3,6-disubstituted and 2, 4, 5-trisubstituted pyran derivatives that exhibit potent activity on monoamine transport systems are provided. The 3, 6 and 2, 4, 5 pyrans are useful in probing the effects of their binding to monoamine transporter system

THERAPEUTIC AGENT FOR CEREBRAL INFARCTION

The invention provides a therapeutic drug for ischemic stroke. The therapeutic drug has the formula (I) wherein each symbol is as defined herein, or a pharmacologically acceptable salt thereof, or a solvate thereof, as an active ingredient.

Original TDAE reactivity in benzoxa- and benzothiazolone series

We present herein an extension of the TDAE strategy using original heterocyclic carbaldehyde as electrophiles. We also evaluate the influence of the presence of nitro group on the reactivity. The TDAE-initiated reactions of various halomethyl and gem-diha

Antioxidant activity of benzoxazolinonic and benzothiazolinonic derivatives in the LDL oxidation model

A series of benzazolone compounds were synthesized utilizing benzoxazolinonic and benzothiazolinonic heterocycles as the building unit. The antioxidant activity of these compounds was determined by inhibition of lipid peroxidation. The oxidation of LDL was induced in the presence of CuSO4 or 2,2′-azobis(2-amidinopropane) dihydrochloride (AAPH). The protective action of these compounds against the cytotoxicity was evaluated with lactate dehydrogenase (LDH) activity in bovine aortic endothelial cells (BAECs) and cellular vitality by measuring mitochondrial activity in the presence of MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide). The best antioxidant activities were observed for phenolic compounds 13 and 14b with ratio R = 2.5, 3.2 (5 μM). Both of these test substances increased the cell viability significantly as indicated by MTT assay and LDH release assay.

NITROGEN-CONTAINING BICYCLIC HETEROCYCLES FOR USE AS ANTIBACTERIALS

Cyclohexane and cyclohexene derivatives and pharmaceutically acceptable derivatives hereof useful in methods of treatment of bacterial infections in mammals, particularly man.

C-formylation of some 2(3H)-benzazolones and 2H-1,4-benzoxazin-3(4H)-one

The C-formylation of 1,3-dimethyl-2(3H)-benzimidazolone and 4-methyl-2H-1,4-benzoxazin-3(4H)-one was performed using 1,1-dichloromethyl methyl ether at the Friedel-Crafts reaction conditions. The formylation of 3-methyl-2(3H)-benzoxa-and -thiazolone at the 6-position was carried out by modified Duffs method with hexamethylenetetramine in trifluoroacetic acid.

SOLVENT EFFECT IN THE WILLGERODT-KINDLER REACTION

The Willgerodt-Kindler reaction was studied on three different model compounds (4-bromobenzaldehyde, 4-fluorobenzaldehyde, 4-methoxyacetophenone) with particular emphasis on the influence of the solvent on the yield of the reaction.Best conditions involved the use of polar aprotic solvents such as DMF.This finding was applied to the Willgerodt-Kindler reaction of two difficult substrates, i.e. 3-methyl-6-formyl-2(3H)-benzoxazolinone and 3-methyl-6-formyl-2(3H)-benzothiazolinone with various secondary amines.