54917-66-7

Upstream product

• 108-24-7 acetic anhydride 
• 119262-68-9 scutellarein 7-O-β-D-glucuronopyranoside methyl ester 
• 1180-46-7 4,5,6,7-tetra-O-acetylflavone 
• 21085-72-3 1-bromo-2,3,4-tri-O-acetyl-α-D-glucuronic acid methyl ester 
• 529-53-3 scutellarein 
• 27740-01-8 scutellarin 

Downstream Products

• 1104900-42-6 6,7,4'-trihydroxy-8-(N,N-dimethylamino)methylflavone 
• 1374218-61-7 6,4'-diacetoxy-7-hydroxyflavon-7-O-(2,3,4-tri-O-acetyl-β-D-glucopyranosiduronsauremethyl ester) 
• 1374218-54-8 6,4'-diacetoxy-7-hydroxyflavon-8-nitro-7-O-(2,3,4-tri-O-acetyl-β-D-glucopyranosiduronsauremethyl ester) 
• 1374218-62-8 6,4'-diacetoxy-7-hydroxyflavon-8-amino-7-O-(2,3,4-tri-O-acetyl-β-D-glucopyranosiduronsauremethyl ester) 
• 1374218-60-6 6,4'-diacetoxy-5-hydroxy-3-oxa-1,2-diaza-cyclopenta[α]flavone 
• 1374218-48-0 5,6,4'-triacetoxy-3-chloro-7-hydroxyflavon-7-O-(2,3,4-tri-O-acetyl-β-D-glucopyranosiduronsauremethyl ester) 
• 1374218-50-4 5,6,4'-triacetoxy-8-bromo-7-hydroxyflavon-7-O-(2,3,4-tri-O-acetyl-β-D-glucopyranosiduronsauremethyl ester) 
• 27740-01-8 scutellarin 
• 119262-68-9 scutellarein 7-O-β-D-glucuronopyranoside methyl ester 

Relevant academic research and scientific papers

Scutellarin compounds and preparation method and application thereof

The invention discloses scutellarin compounds and a preparation method and an application thereof, and belongs to the technical field of medicinal chemistry. The compounds have the structural characteristic represented by the formula I, and have the advan

Preparation of 5, 6, 4 '-three hydroxy flavone-7-0-D-glucuro method

The invention relates to the field of drug synthesis and discloses a method for preparing 5,6,4'-trihydroxy flavone-7-0-D-glucuronic acid. The method is characterized by taking 5,6,7,4'-tetrahydroxy flavone as a raw material, adopting a brand-new syntheti

METHOD FOR PREPARING 5,6,4'-TRIHYDROXYFLAVONE-7-0-D-GLUCURONIC ACID

The present invention relates to the field of drug synthesis. Disclosed is a method for preparing 5,6,4'-trihydroxyflavone-7-O-D-glucuronic acid. The method for preparing 5,6,4'-trihydroxyflavone-7-O-D-glucuronic acid of the present invention uses 5,6,7,4'-tetrahydroxyflavone as a raw material and adopts a new synthetic route to obtain high-purity 5,6,4'-trihydroxyflavone-7-O-D-glucuronic acid through an acylation reaction, a glycosylation reaction, and two-step hydrolysis. The preparing method of the present invention has a short synthetic route, low cost, and high reaction yield, the product is easy for purification, and the method is applicable to industrial production of 5,6,4'-trihydroxyflavone-7-O-D-glucuronic acid.

Synthesis and biological evaluation of 8-substituted and deglucuronidated scutellarin and baicalin analogues as antioxidant responsive element activators

Flavonoids are important bioactive dietary compounds, which are proved to be antioxidant responsive element (ARE) activators to defend against electrophilic toxicants and oxidative stress. The activators induce ARE gene transcription through Nrf2 factor, a major transcriptional stimulator of cytoprotective genes, relieved from a Keap1 complex. In this report, based on the structures of two flavonoids, scutellarin and baicalin, which are extracted from two common Chinese plants Dengzhanhua (Erigeron breviscapus (vant) Hand-Mazz) and Huangqin (Scutellaria baicalensis Georigi), respectively, we synthesized several 8-substituted and deglucuronidated analogues and identified the ARE activation effects of these flavonoids. We found that the Baicalin, deglucurnonidated Baicalin and diaza cyclopenta derivative were more active. Their dose-dependent upregulation activities of ARE and NQO1 and induction effects of Nrf2 were testified. The results presented that these three analogues had good upregulation effects on ARE, and they could be potentially utilized in relieving oxidative stress, upon further neuroprotective tests.