119262-68-9Relevant articles and documents
PEG-scutellarin prodrugs: Synthesis, water solubility and protective effect on cerebral ischemia/reperfusion injury
Lu, Juan,Cheng, Changmei,Zhao, Xinge,Liu, Qingfei,Yang, Ping,Wang, Yiming,Luo, Guoan
, p. 1731 - 1738 (2010)
Fifteen PEG-scutellarin prodrugs were synthesized by modifying carboxyl and phenolic hydroxyl groups of scutellarin with mPEG of different molecular weight (400-3000). The water solubility of prodrugs increased remarkably and reached the maximum value of
Preparation method of homoplantaginin
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Paragraph 0025-0030, (2020/08/18)
The invention relates to the field of chemical synthesis, in particular to a novel preparation method of homoplantaginin. The method employs scutellarin as a raw material and can be used for efficiently semi-synthesizing the homoplantaginin from the scutellarin through three steps of reactions of carboxyl esterification, selective methylation and ester group reduction. The method is short in reaction step, high in reaction yield, mild in reaction condition and easy to operate, provides a necessary material basis for further research on the biological activity of the homoplantaginin, and has arelatively good application and development prospect.
An efficient, scalable approach to hydrolyze flavonoid glucuronides via activation of glycoside bond
Jiang, Xue-Yang,Li, Xin-Chen,Liu, Wen-Yuan,Xu, Yun-Hui,Feng, Feng,Qu, Wei
, p. 1895 - 1903 (2017/03/11)
Hydrolyzing flavonoid glucuronides into corresponding aglycones posed some significant challenges. To improve acid-catalyzed hydrolysis process of flavonoid glucuronide, structures of glucuronide, hydrolysis parameters and post-processing were optimized. The optimized condition was performed by hydrolysis flavonoid glycoside methyl ester in a mixed solvent consisting of 2?mol/L H2SO4/EtOH/H2O (1/8/1, v/v/v) at 95?°C for 7?h and resulted in up to 90% aglycone yields, minimal byproduct formations and milder hydrolysis conditions. Furthermore, the optimized method avoids tedious purification steps and is easily conducted on a relatively large-scale using economical and commercially available reagents.