54920-77-3

Usage

Uses

Used in Organic Synthesis:
2,4-Dibromo-1,7-naphthyridine is used as a building block in organic synthesis for the preparation of various pharmaceuticals and agrochemicals. Its unique structure allows for the creation of a wide range of compounds with potential therapeutic and pesticidal properties.
Used in Reagent Preparation:
In the laboratory, 2,4-Dibromo-1,7-naphthyridine serves as a reagent for the preparation of other compounds with potential biological activity. Its presence in these reactions can lead to the development of new molecules with applications in medicine and agriculture.
Used in Research and Development:
2,4-Dibromo-1,7-naphthyridine is utilized in research and development settings to explore its chemical properties and potential applications. Its moderate toxicity necessitates careful handling and use, making it a subject of interest for safety protocols in laboratory practices.

Upstream product

• 54920-76-2 [1,7]naphthyridine-2,4-diol 
• 55279-30-6 methyl 3-aminoisonicotinate 

Downstream Products

• 67967-12-8 4-bromo-1H-[1,7]naphthyridin-2-one 
• 1353969-32-0 4-[2-(5-chloro-2-fluoro-phenyl)-[1,8]naphthyridin-4-yl]-2-(2-morpholin-4-yl-ethoxy)-[1,7]naphthyridine 
• 1353969-27-3 4-[2-(5-chloro-2-fluoro-phenyl)-[1,8]naphthyridin-4-yl]-1-(2-morpholin-4-yl-ethyl)-1H-[1,7]naphthyridin-2-one 

Relevant academic research and scientific papers

Identification and Optimization of the First Highly Selective GLUT1 Inhibitor BAY-876

Despite the long-known fact that the facilitative glucose transporter GLUT1 is one of the key players safeguarding the increase in glucose consumption of many tumor entities even under conditions of normal oxygen supply (known as the Warburg effect), only

GLUCOSE TRANSPORT INHIBITORS

The present invention relates to chemical compounds that selectively inhibit glucose transporter 1 (GLUT1), to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds, to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, as well as to intermediate compounds useful in the preparation of said compounds.

2,4-DIARYL - SUBSTITUTED [1,8] NAPHTHYRIDINES AS KINASE INHIBITORS FOR USE AGAINST CANCER

The present invention relates to novel [1,8]naphthyridine derivatives of formula (I) and to the use of such compounds in which the inhibition, regulation and/or modulation of signal transduction by ATP consuming proteins like kinases plays a role, particu

2,4- DIARYL-SUBSTITUTED [1,8] NAPHTHYRIDINES AS KINASE INHIBITORS FOR USE AGAINST CANCER

The present invention relates to novel [1,8]naphthyridine derivatives of formula (I) and to the use of such compounds in which the inhibition, regulation and/or modulation of signal transduction by ATP consuming proteins like kinases playsa role, particularly to inhibitors of TGF-beta receptor kinases, and to the use of such compounds for the treatment of kinase-induced diseases, in particular for the treatment of tumors