54920-76-2

Usage

Uses

Used in Medicinal Chemistry:
1,7-Naphthyridin-2(1H)-one, 4-hydroxyis used as a building block for the synthesis of pharmaceutical compounds. Its unique structure and functional groups make it a valuable component in the development of new drugs with potential therapeutic effects.
Used in Drug Design:
1,7-Naphthyridin-2(1H)-one, 4-hydroxyis used as a pharmacophore in drug design. Its presence in a compound can contribute to the overall biological activity and therapeutic potential of the drug, making it an important factor in the design and optimization of new pharmaceutical agents.
Used in Research and Development:
1,7-Naphthyridin-2(1H)-one, 4-hydroxyis used in research and development for the exploration of its biological activities and therapeutic potential. Further studies are needed to fully understand its properties and potential uses in various medical applications, which may lead to the discovery of new treatments and therapies.

Upstream product

• 55279-30-6 methyl 3-aminoisonicotinate 
• 141-78-6 ethyl acetate 
• 865-47-4 potassium tert-butylate 
• 54920-75-1 ethyl 2,4-dihydroxy-1,7-naphthyridine-3-carboxylate 

Downstream Products

• 16287-97-1 4-chloro-[1,7]naphthyridine 
• 1353969-27-3 4-[2-(5-chloro-2-fluoro-phenyl)-[1,8]naphthyridin-4-yl]-1-(2-morpholin-4-yl-ethyl)-1H-[1,7]naphthyridin-2-one 
• 1353969-30-8 4-[2-(2-fluoro-phenyl)-[1,8]naphthyridin-4-yl]-[1,7]naphthyridine 
• 1353969-32-0 4-[2-(5-chloro-2-fluoro-phenyl)-[1,8]naphthyridin-4-yl]-2-(2-morpholin-4-yl-ethoxy)-[1,7]naphthyridine 
• 1353969-35-3 4-[2-(2-fluoro-phenyl)-[1,8]naphthyridin-4-yl]-[1,7]naphthyridin-8-ylamine 
• 54920-77-3 2,4-dibromo-[1,7]naphthyridine 
• 67967-12-8 4-bromo-1H-[1,7]naphthyridin-2-one 
• 54920-78-4 2,4-dichloro-[1,7]naphthyridine 
• 1353970-49-6 4-[2-(2-fluoro-phenyl)-[1,8]naphthyridin-4-yl]-[1,7]naphthyridine 7-oxide 

Relevant academic research and scientific papers

ISOQUINOLINE DERIVATIVES AS SIK2 INHIBITORS

Provided are compounds of the Formula I, and salts and solvates thereof: (I) wherein R1, R2, R3, X1, X2, X3 and Z are defined in the specification. The compounds are inhibitors of salt-inducible kinase (SIK), particular SIK2, and are useful in therapy, particularly in the treatment of a proliferative disorder, a benign neoplasm, pathological angiogenesis, an inflammatory disease or condition, a musculoskeletal disease or condition, an autoimmune disease, a haematological disease or condition, a neurological disease or condition, a psychiatric disorder, or a metabolic disorder.

INHIBITORS OF LOW MOLECULAR WEIGHT PROTEIN TYROSINE PHOSPHATASE (LMPTP) AND USES THEREOF

Protein tyrosine phosphatases (PTPs) are key regulators of metabolism and insulin signaling. As a negative regulator of insulin signaling, the low molecular weight protein tyrosine phosphatase (LMPTP) is a target for insulin resistance and related conditions. Described herein are compounds capable of modulating the level of activity of low molecular weight protein tyrosine phosphatase (LMPTP) and compositions, and methods of using these compounds and compositions.

Identification and Optimization of the First Highly Selective GLUT1 Inhibitor BAY-876

Despite the long-known fact that the facilitative glucose transporter GLUT1 is one of the key players safeguarding the increase in glucose consumption of many tumor entities even under conditions of normal oxygen supply (known as the Warburg effect), only

GLUCOSE TRANSPORT INHIBITORS

The present invention relates to chemical compounds that selectively inhibit glucose transporter 1 (GLUT1), to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds, to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, as well as to intermediate compounds useful in the preparation of said compounds.

2,4-DIARYL - SUBSTITUTED [1,8] NAPHTHYRIDINES AS KINASE INHIBITORS FOR USE AGAINST CANCER

The present invention relates to novel [1,8]naphthyridine derivatives of formula (I) and to the use of such compounds in which the inhibition, regulation and/or modulation of signal transduction by ATP consuming proteins like kinases plays a role, particu

2,4- DIARYL-SUBSTITUTED [1,8] NAPHTHYRIDINES AS KINASE INHIBITORS FOR USE AGAINST CANCER

The present invention relates to novel [1,8]naphthyridine derivatives of formula (I) and to the use of such compounds in which the inhibition, regulation and/or modulation of signal transduction by ATP consuming proteins like kinases playsa role, particularly to inhibitors of TGF-beta receptor kinases, and to the use of such compounds for the treatment of kinase-induced diseases, in particular for the treatment of tumors