54920-82-0

Basic information

• Product Name: 1,7-NAPHTHYRIDIN-2(1H)-ONE
• Synonyms: 1,7-NAPHTHYRIDIN-2(1H)-ONE;1,3-Naphthyridine-2(1H)-one;1,2-dihydroquinazolin-2-one;1,7-Naphthyridin-2(1H)
• CAS NO: 54920-82-0
• Molecular Formula: C₈H₆N₂O
• Molecular Weight: 146.15
• Mol File: 54920-82-0.mol

Chemical Properties

• Melting Point: 290-291 °C(Solv: water (7732-18-5))
• Boiling Point: 391.8°C at 760 mmHg
• Flash Point: 190.8°C
• Appearance: /
• Density: 1.267g/cm³
• Vapor Pressure: 2.4E-06mmHg at 25°C
• Refractive Index: 1.602
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 11.27±0.20(Predicted)
• CAS DataBase Reference: 1,7-NAPHTHYRIDIN-2(1H)-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,7-NAPHTHYRIDIN-2(1H)-ONE(54920-82-0)
• EPA Substance Registry System: 1,7-NAPHTHYRIDIN-2(1H)-ONE(54920-82-0)

Safety Data

• Hazardous Substances Data: 54920-82-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
1,7-NAPHTHYRIDIN-2(1H)-ONE is used as a building block for the synthesis of various pharmaceuticals due to its diverse biological activities, including anti-inflammatory, antimicrobial, and antifungal properties. Its potential as a drug candidate for the treatment of various diseases makes it a valuable tool in medicinal chemistry research.
Used in Agrochemical Industry:
1,7-NAPHTHYRIDIN-2(1H)-ONE is used as a key intermediate in the synthesis of agrochemicals, contributing to the development of effective and innovative products for agricultural applications. Its biological activities, such as antimicrobial and antifungal properties, make it a promising component in the creation of new agrochemical formulations.

InChI:InChI=1/C8H6N2O/c11-8-2-1-6-3-4-9-5-7(6)10-8/h1-5H,(H,10,11)

Upstream product

• 105752-11-2 4-iodopyridin-3-amine 
• 239137-39-4 3-amino-4-bromopyridine 
• 1452560-16-5 ethyl (E)-3-(3-amino-4-pyridyl)prop-2-enoate 
• 153813-70-8 3-nitro-4-pyridinecarboxaldehyde 
• 5832-44-0 3-nitro-4-methylpyridine 

Downstream Products

• 869640-41-5 7-benzyl-5,6,7,8-tetrahydro-1,7-naphthyridine-2(1H)-one 
• 959615-71-5 (2-oxo-1,7-naphthyridin-1(2H)-yl)acetaldehyde 

Relevant articles and documents

1, 2 - DIHYDRO- 3H- PYRAZOLO [3, 4 - D] PYRIMIDIN -3 - ONE ANALOGS

Compounds of Formula (I) are provided herein. Such compounds, as well as pharmaceutically acceptable salts and compositions thereof, are useful for treating diseases or conditions, including conditions characterized by excessive cellular proliferation, such as breast cancer.

NRF2 ACTIVATOR

Provided are tetrahydroisoquinoline derivatives as Nrf2 activators.

NOVEL TETRAHYDROISOQUINOLINES AND TERAHYDRONAPHTHYRIDINES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION

The present invention provides novel compounds having the general formula (I): wherein R1, R 2, R 3, U, V, W, X and Y are as described herein, compositions including the compounds and methods of using the compounds.

Tetrahydronaphthyridine derivates useful as histamine H3 receptor ligands

The invention relates to tetrahydronaphthyridine derivatives having formula (I) and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. Said tetrahydronaphthyridine derivatives are H3 ligands and are useful in numerous diseases, disorders and conditions, in particular inflammatory, allergic and respiratory diseases, disorders and conditions.