54921-95-8

Upstream product

• 135-77-3 1,2,4-trimethoxy-benzene 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 1224969-76-9 C₂₅H₂₈O₇S 
• 137845-39-7 N-(3,4-dimethoxybenzylidene)-4-methylbenzenesulfonamide 
• 93-03-8 (3,4-dimethoxyphenyl)methanol 

Relevant academic research and scientific papers

Novel and highly efficient one pot protocol for the synthesis of diversely functionalized triarylmethanes

An efficient, convenient, and novel one pot approach is described for the synthesis of triarylmethanes by in situ oxidation of benzylalcohols followed by the Friedel-Crafts alkylation of di/trimethoxybenzenes in the presence of BF3·OEt2. The generality of the present method is strengthened by screening a variety of aromatic, aliphatic, and heteroaromatic alcohols with methoxy arenes. Shorter reaction time, mild reaction condition, good yields, and wide scope of substrates are the significant features of this protocol.

Trifluoromethanesulfonic acid catalyzed Friedel-Crafts alkylations of 1,2,4-trimethoxybenzene with aldehydes or benzylic alcohols

Trifluoromethanesulfonic acid in acetonitrile was found to efficiently catalyze Friedel-Crafts alkylations of 1,2,4-trimethoxybenzene with a variety of simple or functionalized aldehydes to provide di- or triarylmethanes in high yields. The operationally

Friedel-crafts arylation reactions of N -sulfonyl aldimines or sulfonamidesulfones with electron-rich arenes catalyzed by FeCl 3·6H2O: Synthesis of triarylmethanes and bis-heteroarylarylmethanes

(Figure presented) The FeCl3·6H2O-catalyzed Friedel-Crafts arylation reactions of N-sulfonyl aldimines or sulfonamidesulfones with electron-rich arenes and heteroarenes, which lead to the formation of triarylmethanes and bis-heteroar

Regioselective arylations of α-amido sulfones with electron-rich arenes through friedel-crafts alkylations catalyzed by ferric chloride hexahydrate: Synthesis of unsymmetrical and bis-symmetrical triarylmethanes

Ferric chloride hexahydrate is a highly efficient catalyst for the regioselective arylation of α-amido sulfones. The products undergo further Friedel-Crafts alkylations with heteroaromatic or electron-rich arenes to afford unsymmetrical or bis-symmetrical

Iodine-catalyzed Friedel-Crafts alkylation of electron-rich arenes with aldehydes: efficient synthesis of triarylmethanes and diarylalkanes

Iodine is shown to be an efficient catalyst for the Friedel-Crafts alkylation of arenes with a wide variety of aldehydes in toluene under 'open-flask' and mild conditions. In the presence of 10 mol % of iodine, the reaction of arenes with aromatic aldehyd