54931-62-3

Usage

Uses

Used in Pharmaceutical Industry:
2-methyl-1-oxo-1,2-dihydroisoquinoline-4-carboxylic acid (SALTDATA: FREE) is used as a bioactive compound for the development of various drugs due to its potential therapeutic properties. Its specific applications may include the treatment of various diseases and conditions, depending on the salts or derivatives it is combined with.
Used in Drug Synthesis:
In the pharmaceutical industry, 2-methyl-1-oxo-1,2-dihydroisoquinoline-4-carboxylic acid (SALTDATA: FREE) is used as a key intermediate in the synthesis of different drugs. Its unique structure and bioactive properties allow for the creation of novel therapeutic agents with potential benefits in various medical fields.

InChI:InChI=1/C11H9NO3/c1-12-6-9(11(14)15)7-4-2-3-5-8(7)10(12)13/h2-6H,1H3,(H,14,15)

Upstream product

• 861542-86-1 2-methyl-1-oxo-1,2-dihydro-isoquinoline-4-carboxylic acid ethyl ester 
• 74-89-5 methylamine 
• 58399-95-4 4-(dimethylaminomethylene)isochroman-1,3-dione 
• 89-51-0 Homophthalic acid 
• 15868-29-8 1-oxo-1H-isochromene-4-carboxylic acid 

Downstream Products

• 90686-94-5 p-nitrobenzyl 7-(2-methyl-1-<2H>isoquinolinonyl-4-carboxamido)-3-methylceph-3-eme-4-carboxylate 

Relevant academic research and scientific papers

The reaction of homophthalic acid and some aza analogues with vilsmeier reagent: A reinvestigation

Homophthalic acid and its pyrido and 8-methylquinolino analogues with dimethylformamide/phosphoryl chloride at 0° give the appropriate 4-(dimethylaminomethylene)isochroman-1,3-dione (2a, 2b, 2c, respectively). Under the literature conditions for conversion of 2a to 2-methyl-1-oxo-1,2-dihydroisoquinoline-4-carboxylic acid (3a), the aza analogues give instead 7-hydroxy-5-oxo-5H-pyrano[4,3-b]pyridine-8-carboxaldehyde (5b) and 3-hydroxy-6-methyl-1-oxo-1H-pyrano[4,3-b]quinoline-4-carboxaldehyde (5c), respectively. Modified conditions were required to isolate analogues 3b and 3c. Further, while reaction of 2a with hydrogen chloride in methanol gave the known change to methyl 1-oxo-1H-isochromene-4-carboxylate (4), 2b and 2c gave only products of oxa-ring cleavage. Methyl 2-(cis-2-hydroxyvinyl)-8-methylquinoline-3-carboxylate (8) was the main product from 2c, while a novel quinolizinium species (11) was formed in good yield from 2b.

Research on isoquinoline derivatives. V. Synthesis and pharmacological evaluation of a series of amidic derivatives of isoquinolin and isocoumarin carboxylic acids

The synthesis of some amidic derivatives of N-methyl-isoquinolin-1(2H)-one-4-carboxylic acid and of isocoumarin-4-carboxylic acid are reported. These compounds have been evaluated for analgesic, antiinflammatory and antipyretic activities. The central nervous system effects have been also investigated.