549506-52-7 Usage
Chemical structure
A complex structure consisting of a piperazine group, an acetamide group, an aminoiminomethyl group, and a thiazolylcarbonyl group, with a sulfonyl group and a 4-chlorophenyl group.
Bromodomain-containing protein 4 (BRD4) inhibitor
A potent inhibitor of the enzyme BRD4, which is involved in the regulation of gene expression and has been linked to cancer and other diseases.
Potential drug candidate
Due to its chemical structure and properties, it is a promising candidate for the development of new drugs for the treatment of BRD4-related diseases.
Check Digit Verification of cas no
The CAS Registry Mumber 549506-52-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 5,4,9,5,0 and 6 respectively; the second part has 2 digits, 5 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 549506-52:
(8*5)+(7*4)+(6*9)+(5*5)+(4*0)+(3*6)+(2*5)+(1*2)=177
177 % 10 = 7
So 549506-52-7 is a valid CAS Registry Number.
549506-52-7Relevant academic research and scientific papers
Design, synthesis, and structure-activity relationships of unsubstituted piperazinone-based transition state factor Xa inhibitors
Huang, Wenrong,Naughton, Mary Ann,Yang, Hua,Su, Ting,Dam, Suiko,Wong, Paul W.,Arfsten, Ann,Edwards, Susan,Sinha, Uma,Hollenbach, Stanley,Scarborough, Robert M.,Zhu, Bing-Yan
, p. 723 - 728 (2007/10/03)
A series of novel transition state factor Xa inhibitors containing a variety of lactam ring systems as central templates was synthesized in an expedient manner and allowed for a great deal of structural variability. Among them, the piperazinone-based inhibitors were found to be not only active against factor Xa but also selective over thrombin. Optimization of the P4 moiety yielded several potent compounds with IC50 below 1 nM against factor Xa.
