549544-14-1

Basic information

• Product Name: 3-chloro-1-(4-(4-chlorophenyl)piperazin-1-yl)propan-1-one
• Synonyms: 3-chloro-1-(4-(4-chlorophenyl)piperazin-1-yl)propan-1-one
• CAS NO: 549544-14-1
• Molecular Weight: 287.189
• Mol File: 549544-14-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3-chloro-1-(4-(4-chlorophenyl)piperazin-1-yl)propan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-chloro-1-(4-(4-chlorophenyl)piperazin-1-yl)propan-1-one(549544-14-1)
• EPA Substance Registry System: 3-chloro-1-(4-(4-chlorophenyl)piperazin-1-yl)propan-1-one(549544-14-1)

Safety Data

• Hazardous Substances Data: 549544-14-1(Hazardous Substances Data)

Upstream product

• 38212-33-8 4-(4-chlorophenyl) piperazine 
• 625-36-5 2-chloropropionyl chloride 
• 13078-12-1 1-(4-chlorophenyl)piperazine dihydrochloride 

Downstream Products

• 1353278-89-3 3-amino-1-[{4-(4-chlorophenyl)piperazin-1-yl}propanoyl]-6-N-(p-tolyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridin-7-one 

Relevant articles and documents

Synthesis of 1,6-disubstituted 4,5,6,7-tetrahydropyrazolo[3,4-c]pyridin-7- one derivatives and evaluation of their anticancer activity

Promising anticancer compounds of the type 1,6-disubstituted 4,5,6,7-tetrahydropyrazolo[3,4-c]pyridin-7-ones were identified. The target compounds were readily synthesized in a large scale via a sequence of reactions starting from the commercially available primary amines. Their in vitro anti-proliferative activity has been evaluated on prostate (DU-145), colon (HT-29 and HCT-116) and melanoma (A375P) human cancer cell lines. The relationships between the structure and the anticancer activity, covering all tested cancer cell lines, revealed that the compound 5c with 2,4-dimethylphenyl substituent at R2 was the most potent with the IC50 values in the range as low as 0.16 to 0.40 μM.