54958-15-5

Basic information

• Product Name: Iodonium, di-2,4-xylyl- bromide
• CAS NO: 54958-15-5
• Molecular Formula: C₁₆H₁₈I-
• Molecular Weight: 417.127
• Mol File: 54958-15-5.mol

Chemical Properties

• CAS DataBase Reference: Iodonium, di-2,4-xylyl- bromide(CAS DataBase Reference)
• NIST Chemistry Reference: Iodonium, di-2,4-xylyl- bromide(54958-15-5)
• EPA Substance Registry System: Iodonium, di-2,4-xylyl- bromide(54958-15-5)

Safety Data

• Hazardous Substances Data: 54958-15-5(Hazardous Substances Data)

Upstream product

• 108-38-3 m-xylene 
• 4214-28-2 1-iodo-2,4-dimethylbenzene 

Downstream Products

• 1318254-96-4 2,6-dichloro-9-(2,4-dimethylphenyl)-9H-purine 
• 4214-28-2 1-iodo-2,4-dimethylbenzene 
• 1019453-85-0 2-(2,4-dimethylphenylsulphanyl)benzeneamine 
• 1141-88-4 2-Aminophenyl disulfide 
• 214360-64-2 2-(2,4-bismethylphenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane 

Relevant articles and documents

SALT, ACID GENERATOR, RESIST COMPOSITION, AND METHOD FOR PRODUCING RESIST PATTERN

To provide a salt capable of producing a resist pattern having good CD uniformity (CDU), and a resist composition containing the salt.SOLUTION: The salt represented by formula (I), an acid generator, and the resist composition are provided. [In the formula, R1 and R2 each represent an alkyl group; R3 and R4 each represent a halogen atom, a fluorinated alkyl group or an alkyl group, provided that -CH2- contained in the alkyl group or the fluorinated alkyl group may be substituted with -O- or -CO-; m3 represents an integer of 0-3; m4 represents an integer of 0-5; Q1 and Q2 each represent a fluorine atom or a perfluoroalkyl group; L1 represents a saturated hydrocarbon group, provided that a hydrogen atom contained in the saturated hydrocarbon group may be substituted with a fluorine atom or a hydroxy group; and Y1 represents an optionally substituted methyl group or an optionally substituted alicyclic hydrocarbon group.]SELECTED DRAWING: None

Environmentally Benign Large-Scale Synthesis of a Precursor to Vortioxetine

An eco-friendly, high-yielding, and transition-metal-free synthesis of 2-[(2,4-dimethylphenyl)thio]aniline precursor to vortioxetine is reported. Vortioxetine, a multi-modal acting drug with high affinity for a range of serotonergic targets, is used for the treatment of major depressive disorder (MDD). The synthesis - applicable in multi-gram scale - involves the reaction of bis(2,4-dimethyl)iodonium bromide with commercial 2-aminophenyl disulfide, whereas its reaction with 2-aminothiophenol afforded the same product but in low to moderate yields. This method works equally well in deep eutectic solvents (DESs), based on choline chloride (ChCl).

A ONE-POT ORGANO-PSEUDOCATALYTIC C-H ACTIVATION APPROACH FOR THE PREPARATION OF VORTIOXETINE AND VORTIOXETINE INTERMEDIATE

The present invention relates to a novel process for the preparation of Vortioxetine and a key intermediate thereof by employing a novel one-pot organo-pseudocatalytic C-H activation approach via hypervalent iodine chemistry.

A mild carbon-boron bond formation from diaryliodonium salts

The direct metal-free borylation of diaryliodonium salts with diboron reagents is now demonstrated to be a feasible process toward formation of aryl boronic esters without any additive or catalysts, and it can be extended to a two-step C-C coupling of both aryl groups of the initial diaryliodonium reagent.

CuBr catalyzed C-N cross coupling reaction of purines and diaryliodonium salts to 9-arylpurines

CuBr was found to be an efficient catalyst for the C-N cross coupling reaction of purine and diaryliodonium salts. 9-Arylpurines were synthesized in excellent yields with short reaction times (2.5 h). The method represents an alternative to the synthesis of 9-arylpurines via Cu(ii) catalyzed C-N coupling reaction with arylboronic acids as arylating agents. The Royal Society of Chemistry 2011.

Facile syntheses of symmetrical diaryliodonium salts from various arenes, with sodium metaperiodate as the coupling reagent in acidic media

An easy, inexpensive, safe, and effective preparative procedure to obtain symmetrical diaryliodonium bromides (in 17-88% crude yields) from various arenes is presented in this paper. A novel method for the in situ preparation of iodosyl sulfate (Chretien's reagent) is given. Eleven exemplary crude diaryliodonium bromides were readily oxidatively metathesized with 40% aqueous tetrafluoroboric acid and 30% aqueous hydrogen peroxide (in boiling acetone, used both as a solvent and 'halogen scavenger') to give pure diaryliodonium tetrafluoroborates in 15-85% yields. Georg Thieme Verlag Stuttgart.