54961-01-2Relevant articles and documents
Diverse alkanones by catalytic carbon insertion into the formyl C-H bond. Concise access to the natural precursor of achyrofuran
Wommack, Andrew J.,Moebius, David C.,Travis, Austin L.,Kingsbury, Jason S.
supporting information; experimental part, p. 3202 - 3205 (2009/11/30)
Over a century ago, the first reactions of diazomethane with aldehydes delivered methyl ketones. In the interim, aldehydes have been homologated with trimethylsilyldiazomethane, diazoacetates, and aryldiazomethanes, on rare occasion with catalysis. This work describes a mild procedure for convergent ketone assembly from nonstabilized diazoalkanes, including examples of chiral ketone synthesis with disubstituted (internal) nucleophiles. The method's remarkable tolerance to steric crowding is showcased in a simple approach to achyrofuran, a complex dibenzofuran.
Synthesis and biological activity of the structural analogues of (-)-cabenegrin A-I
Gulacsi, Katalin,Litkei, Gyoergy,Antus, Sandor,Szantay, Csaba,Darko, Laszlo L.,Szelenyi, Judith,Hasko, Gyoergy,Vizi, Szilveszter E.
, p. 53 - 61 (2007/10/03)
A series of phenylbutene and butanol derivatives (6a-j, 12, 13, 15, 17, 24b,c, 26, 27a,b) were prepared from the readily available resorcinol derivatives 2a-f and 7-hydroxy-chroman (18). The products were tested for inhibitory activity on the LPS-induced
IRON-MEDIATED AROMATIC ALLYLATION
Dieter, Janice W.,Li, Zhong,Nicholas, Kenneth M.
, p. 5415 - 5418 (2007/10/02)
Electron rich aromatic and heteroaromatic compounds react with (η3-allyl)Fe(CO)4BF4 to produce allylated aromatics in moderate to good yields.Unsymmetrically substituted allyl complexes afford the corresponding butenyl-, 1,1-dimethylallyl-, cinnamyl-, and geranyl-derivatives with moderate to excellent regioselectivity and complete stereoselectivity.
