54963-70-1

Basic information

• Product Name: 4-N-NONYLBENZOYL CHLORIDE
• Synonyms: 4-n-Nonylbenzoylchloride,98%;4-nonylBenzoyl chloride;4-N-NONYLBENZOYL CHLORIDE;P-NONYLBENZOYL CHLORIDE
• CAS NO: 54963-70-1
• Molecular Formula: C₁₆H₂₃ClO
• Molecular Weight: 266.81
• Mol File: 54963-70-1.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 353°C at 760 mmHg
• Flash Point: 167.6°C
• Appearance: /
• Density: 1.009g/cm³
• Vapor Pressure: 3.68E-05mmHg at 25°C
• Refractive Index: 1.505
• Sensitive: Moisture Sensitive
• CAS DataBase Reference: 4-N-NONYLBENZOYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-N-NONYLBENZOYL CHLORIDE(54963-70-1)
• EPA Substance Registry System: 4-N-NONYLBENZOYL CHLORIDE(54963-70-1)

Safety Data

• Statements: 20/21/22-34-36/37
• Safety Statements: 26-27-28-36/37/39
• RIDADR: 1759
• HazardClass: 8
• PackingGroup: II
• Hazardous Substances Data: 54963-70-1(Hazardous Substances Data)

Usage

Description

4-N-Nonylbenzoyl chloride, with the chemical formula C16H25ClO, is a derivative of benzoyl chloride featuring a nonyl group attached at the 4-position of the benzene ring. 4-N-NONYLBENZOYL CHLORIDE plays a significant role in organic synthesis and is valued for its versatility in the preparation of a range of organic compounds, including esters, amides, and ketones.

Uses

Used in Organic Synthesis:
4-N-Nonylbenzoyl chloride is utilized as a reagent in organic synthesis for the preparation of various organic compounds. Its ability to form esters, amides, and ketones makes it a valuable component in the creation of complex organic molecules.
Used in Pharmaceutical Production:
In the pharmaceutical industry, 4-N-Nonylbenzoyl chloride serves as a building block for the development of new drugs. Its structural properties allow it to be incorporated into the synthesis of a variety of pharmaceuticals, contributing to the advancement of medicinal chemistry.
Used in Agrochemical Production:
4-N-NONYLBENZOYL CHLORIDE also finds application in the agrochemical sector, where it is used as a precursor in the synthesis of various agrochemicals. Its role in the production of these chemicals is crucial for the development of effective products for agricultural use.
Used in Specialty Chemicals Production:
4-N-Nonylbenzoyl chloride is employed in the production of specialty chemicals, which are tailored for specific industries and applications. Its unique properties make it suitable for creating customized chemical solutions for diverse market needs.
Safety Precautions:
Given its classification as a hazardous chemical, 4-N-Nonylbenzoyl chloride must be handled and stored with appropriate safety measures. Proper care must be taken to minimize risks associated with its use, ensuring the safety of both individuals and the environment.

InChI:InChI=1/C16H23ClO/c1-2-3-4-5-6-7-8-9-14-10-12-15(13-11-14)16(17)18/h10-13H,2-9H2,1H3

Upstream product

• 79-37-8 oxalyl dichloride 
• 1081-77-2 n-nonylbenzene 
• 844656-92-4 4-nonylbenzoic acid methyl ester 
• 827028-03-5 methyl 4-(non-1-yn-1-yl)benzoate 
• 619-44-3 methyl 4-iodobenzoate 
• 619-58-9 4-iodobenzoic acid 
• 38289-46-2 4-n-Nonylbenzoic acid 

Downstream Products

• 70972-98-4 4-(n-nonyl)benzaldehyde 
• 61518-86-3 4-Nonyl-thiobenzoic acid S-(4-pentyl-phenyl) ester 
• 748733-78-0 4-nonylbenzamide 
• 1537168-38-9 2-{1-[4-methyl-2-(4-nonylphenyl)thiazol-5-yl]ethylidene}hydrazinecarboximidamide 
• 1537168-63-0 1-[4-methyl-2-(4-nonylphenyl)thiazol-5-yl]ethanone 
• 1537168-51-6 4-nonylthiobenzamide 
• 1227623-87-1 N-(2-azidoethyl)-4-nonylbenzamide 
• 786702-97-4 N-methoxy-N-methyl-4-nonyl-benzamide 

Relevant articles and documents

Nonpeptidic, Polo-Box Domain-Targeted Inhibitors of PLK1 Block Kinase Activity, Induce Its Degradation and Target-Resistant Cells

PLK1, polo-like kinase 1, is a central player regulating mitosis. Inhibition of the subcellular localization and kinase activity of PLK1 through the PBD, polo-box domain, is a viable alternative to ATP-competitive inhibitors, for which the development of resistance and inhibition of related PLK family members are concerns. We describe novel nonpeptidic PBD-binding inhibitors, termed abbapolins, identified through successful application of the REPLACE strategy and demonstrate their potent antiproliferative activity in prostate tumors and other cell lines. Furthermore, abbapolins show PLK1-specific binding and inhibitory activity, as measured by a cellular thermal shift assay and an ability to block phosphorylation of TCTP, a validated target of PLK1-mediated kinase activity. Additional evidence for engagement of PLK1 was obtained through the unique observation that abbapolins induce PLK1 degradation in a manner that closely matches antiproliferative activity. Moreover, abbapolins demonstrate antiproliferative activity in cells that are dramatically resistant to ATP-competitive PLK1 inhibitors.

Discovery and characterization of potent thiazoles versus methicillin- and vancomycin-resistant Staphylococcus aureus

Methicillin- and vancomycin-resistant Staphylococcus aureus (MRSA and VRSA) infections are growing global health concerns. Structure-activity relationships of phenylthiazoles as a new antimicrobial class have been addressed. We present 10 thiazole derivatives that exhibit strong activity against 18 clinical strains of MRSA and VRSA with acceptable PK profile. Three derivatives revealed an advantage over vancomycin by rapidly eliminating MRSA growth within 6 h, and no derivatives are toxic to HeLa cells at 11 μg/mL.

Preparation of 4-alkyl-and 4-halobenzoyl chlorides: 4-Pentylbenzoyl chloride

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