54963-70-1

Usage

Uses

Used in Organic Synthesis:
4-N-Nonylbenzoyl chloride is utilized as a reagent in organic synthesis for the preparation of various organic compounds. Its ability to form esters, amides, and ketones makes it a valuable component in the creation of complex organic molecules.
Used in Pharmaceutical Production:
In the pharmaceutical industry, 4-N-Nonylbenzoyl chloride serves as a building block for the development of new drugs. Its structural properties allow it to be incorporated into the synthesis of a variety of pharmaceuticals, contributing to the advancement of medicinal chemistry.
Used in Agrochemical Production:
4-N-NONYLBENZOYL CHLORIDE also finds application in the agrochemical sector, where it is used as a precursor in the synthesis of various agrochemicals. Its role in the production of these chemicals is crucial for the development of effective products for agricultural use.
Used in Specialty Chemicals Production:
4-N-Nonylbenzoyl chloride is employed in the production of specialty chemicals, which are tailored for specific industries and applications. Its unique properties make it suitable for creating customized chemical solutions for diverse market needs.
Safety Precautions:
Given its classification as a hazardous chemical, 4-N-Nonylbenzoyl chloride must be handled and stored with appropriate safety measures. Proper care must be taken to minimize risks associated with its use, ensuring the safety of both individuals and the environment.

InChI:InChI=1/C16H23ClO/c1-2-3-4-5-6-7-8-9-14-10-12-15(13-11-14)16(17)18/h10-13H,2-9H2,1H3

Upstream product

• 844656-92-4 4-nonylbenzoic acid methyl ester 
• 827028-03-5 methyl 4-(non-1-yn-1-yl)benzoate 
• 619-44-3 methyl 4-iodobenzoate 
• 619-58-9 4-iodobenzoic acid 
• 38289-46-2 4-n-Nonylbenzoic acid 
• 79-37-8 oxalyl dichloride 
• 1081-77-2 n-nonylbenzene 

Downstream Products

• 70972-98-4 4-(n-nonyl)benzaldehyde 
• 61518-86-3 4-Nonyl-thiobenzoic acid S-(4-pentyl-phenyl) ester 
• 786702-97-4 N-methoxy-N-methyl-4-nonyl-benzamide 
• 748733-78-0 4-nonylbenzamide 
• 1537168-38-9 2-{1-[4-methyl-2-(4-nonylphenyl)thiazol-5-yl]ethylidene}hydrazinecarboximidamide 
• 1537168-63-0 1-[4-methyl-2-(4-nonylphenyl)thiazol-5-yl]ethanone 
• 1537168-51-6 4-nonylthiobenzamide 
• 1227623-87-1 N-(2-azidoethyl)-4-nonylbenzamide 

Relevant academic research and scientific papers

Nonpeptidic, Polo-Box Domain-Targeted Inhibitors of PLK1 Block Kinase Activity, Induce Its Degradation and Target-Resistant Cells

PLK1, polo-like kinase 1, is a central player regulating mitosis. Inhibition of the subcellular localization and kinase activity of PLK1 through the PBD, polo-box domain, is a viable alternative to ATP-competitive inhibitors, for which the development of resistance and inhibition of related PLK family members are concerns. We describe novel nonpeptidic PBD-binding inhibitors, termed abbapolins, identified through successful application of the REPLACE strategy and demonstrate their potent antiproliferative activity in prostate tumors and other cell lines. Furthermore, abbapolins show PLK1-specific binding and inhibitory activity, as measured by a cellular thermal shift assay and an ability to block phosphorylation of TCTP, a validated target of PLK1-mediated kinase activity. Additional evidence for engagement of PLK1 was obtained through the unique observation that abbapolins induce PLK1 degradation in a manner that closely matches antiproliferative activity. Moreover, abbapolins demonstrate antiproliferative activity in cells that are dramatically resistant to ATP-competitive PLK1 inhibitors.

Potentiation of the fosmidomycin analogue FR 900098 with substituted 2-oxazolines against Francisella novicida

A library of 33 compounds was screened for potentiation of the antibiotic FR 900098 against the Francisella tularensis surrogate Francisella novicida. From the screen a highly potent 2-oxazoline adjuvant was discovered capable of potentiating FR 900098 with a 1000-fold reduction in MIC against the Francisella sub-species F. novicida and F. philomiragia.

Discovery and characterization of potent thiazoles versus methicillin- and vancomycin-resistant Staphylococcus aureus

Methicillin- and vancomycin-resistant Staphylococcus aureus (MRSA and VRSA) infections are growing global health concerns. Structure-activity relationships of phenylthiazoles as a new antimicrobial class have been addressed. We present 10 thiazole derivatives that exhibit strong activity against 18 clinical strains of MRSA and VRSA with acceptable PK profile. Three derivatives revealed an advantage over vancomycin by rapidly eliminating MRSA growth within 6 h, and no derivatives are toxic to HeLa cells at 11 μg/mL.

Discotic Liquid Crystals: Relation between Molecular Structure and Discogenic Properties of Disk-shaped Compounds, Non-liquid Crystalline Esters of myo-Inositol and Mytilitol

A modified synthesis of mytilitol and the synthesis of various esters of the cyclitols myo-inositol (1a) and mytilitol (2a) is described.Because of steric reasons all these derivatives of the two naturally occuring compounds exhibit no discotic mesophases

Synthesis of Unbranched 4-Alkylbenzaldehydes

The preparation of unbranched 4-alkylbenzaldehydes free of positional and branched-chain isomers by different methods is described.A one-step preparation of the aldehydes is reported which involves the direct hydrogenation of a Friedel-Craft's complex in the presence of Pd/C catalyst.

First Liquid Crystal Azulene Derivatives

Various azulene derivatives as a new type of coloured liquid crystals have been synthesized.Their mesomorphic behaviour is described. - Keywords: Azulenes, Coloured Liquid Crystals, Nematic Phases

SYNTHESIS AND MESOMORPHIC PROPERTIES OF THE HOMOLOGOUS SERIES OF 4-ALKYL OR ALKOXY-4 prime -BROMO OR CYANOTOLANES.

A homologous series of 4-alkyl or alkoxy-4 prime -bromo or cyanotolanes in which the alkyl group is C//4 yields C//1//0 and the alkoxy group is C//1 yields C//1//2, was prepared. Interphase transitions between solid, mesomorphic and isotropic phases were studied by hot stage microscopy and differential scanning calorimeter. The bromo compounds have a smectic polymorphism. Three pure products of cyano derivatives with the chains C//9H//1//9O, C//1//0H//2//1O amd C//1//0H//2//1 present an enantiotropic or monotropic reentrant nematic phase at atmospheric pressure. The reentrant phenomenon itself is discussed as well as the absence of correlation between T//N//A/T//N//I McMillan parameter and the heat of transition. A plot of the nematic isotropic transition temperatures against the number of carbon atoms in the alkoxy chain shows the usual odd even effect.