54978-36-8

Usage

Benzene derivative

The compound is derived from benzene, a basic six-carbon ring structure, with various substituents attached to it.

Methyl group

A single carbon atom bonded to three hydrogen atoms (-CH3) one of the substituents attached to the benzene ring in 1-iodo-2-methyl-4-(trifluoromethyl)benzene.

Trifluoromethyl group

A carbon atom bonded to three fluorine atoms (-CF3) another substituent attached to the benzene ring in 1-iodo-2-methyl-4-(trifluoromethyl)benzene.

Iodine atom

A halogen element (I) in this case, attached to the 1 position of the benzene ring, which influences the compound's reactivity and properties.

Organic synthesis utility

1-iodo-2-methyl-4-(trifluoromethyl)benzene is commonly used as a building block in organic synthesis for creating various pharmaceutical and agrochemical products.

Reagent for trifluoromethylation

The compound serves as a reagent in chemical reactions to introduce the trifluoromethyl group onto other organic molecules, enhancing their properties or reactivity.

Potential toxicity

Due to the presence of iodine and the trifluoromethyl group, the compound may exhibit toxic properties and should be handled with caution.

Reactivity

The presence of the iodine atom and the trifluoromethyl group makes the compound highly reactive, requiring careful handling during chemical reactions.

Safety measures

Proper safety measures should be taken while handling 1-iodo-2-methyl-4-(trifluoromethyl)benzene to minimize the risk of exposure, accidents, or harmful effects.

Upstream product

• 67169-22-6 2-methyl-4-(trifluoromethyl)benzenamine 
• 52107-87-6 4-iodo-3-methylbenzoic acid 
• 163444-17-5 2-iodo-4-(trifluoromethyl)aniline 
• 1493-13-6 trifluorormethanesulfonic acid 
• 401-79-6 1-methyl-3-trifluoromethyl-benzene 

Downstream Products

• 23984-82-9 2-methyl-4-(trifluoromethyl)benzoic acid 
• 943917-58-6 1-(bromomethyl)-2-iodo-3-nitro-5-(trifluoromethyl)benzene 
• 943917-57-5 2-methyl-4-trifluoromethyl-6-nitro-phenyl iodide 

Relevant academic research and scientific papers

Deoxofluorination of (Hetero)aromatic Acids

Diverse trifluoromethyl-substituted compounds were synthesized by deoxofluorination of cinnamic and (hetero)aromatic carboxylic acids with sulfur tetrafluoride. The obtained products were used as starting materials in the preparation of novel fluorinated amino acids, anilines, and aliphatic amines - valuable building blocks for medicinal chemistry and agrochemistry.

CETP INHIBITORS

Compounds having the structure of Formula I, including pharmaceutically acceptable salts of the compounds, are CETP inhibitors, and are useful for raising HDL-cholesterol, reducing LDL-cholesterol, and for treating or preventing atherosclerosis. The compounds have 3 cyclic groups connected by single bonds, as for example triphenyl, which are attached directly to the ring of formula I or attached at the position B.

ANTIDIABETIC BICYCLIC COMPOUNDS

Bicyclic compounds containing a phenyl or pyridyl ring fused to a cycloalkyl or heterocyclic ring, to which is attached a 5-membered heterocyclic ring, including pharmaceutically acceptable salts and prodrugs thereof, are agonists of G-protein coupled receptor 40 (GPR40) and are useful as therapeutic compounds, particularly in the treatment of Type 2 diabetes mellitus, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia.

TETRAHYDROPYRANYL CYCLOPENTYL TETRAHYDROISOQUINOLINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY

The present invention is directed to compounds of the formula I: I(wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, X, n and the dashed line are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptor CCR-2.