54979-73-6Relevant academic research and scientific papers
Synthesis and biological relationships of 3′,6-substituted 2-phenyl-4-quinolone-3-carboxylic acid derivatives as antimitotic agents
Lai, Ya-Yun,Huang, Li-Jiau,Lee, Kuo-Hsiung,Xiao, Zhiyan,Bastow, Kenneth F.,Yamori, Takao,Kuo, Sheng-Chu
, p. 265 - 275 (2007/10/03)
As part of a continuing search for potential anticancer drug candidates in the 2-phenyl-4-quinolone series, 3′,6-substituted 2-phenyl-4-quinolone-3- carboxylic acid derivatives and their salts were synthesized and evaluated. Preliminary screening showed t
Substituted 2-phenyl-4-quinolone-3-carboxylic acid compounds and their use as antitumor agents
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Page/Page column 6, (2008/06/13)
Substituted 2-phenyl-4-quinolone-3-carboxylic acid derivatives and their salts were synthesized. The results of preliminary screening revealed that these compounds are potent in killing solid tumor cancers.
Diazotisation Rearrangement of Tosylhydrazones of ortho- and meta-Substituted-benzophenones and α-Substituted-acetophenones (Synthesis of Anilides)
Joshi, Vidya,Sharma, R. K.
, p. 564 - 566 (2007/10/02)
Ortho and meta-substituted-benzophenones (1a-g) and substituted-acetophenones (1h-i) were converted into tosylhydrazones (2a-i) by reacting with p-toluenesulphonyl-hydrazide.Conversion of 2a-i to the anilides (3a-i) was effected with the reagents H2SO4 and NaNO2, and was found to be as facile as in case of the para-substituted-benzophenone hydrozones.
Reaction Pathways for Arylcarbamoyl Radicals and the Cyclization of o-Substituted Phenylcarbamoyl Radicals
Leardini, Rino,Tundo, Antonio,Zanardi, Giuseppe
, p. 3164 - 3167 (2007/10/02)
N-Arylcarbamoyl radicals generated from N-arylformamides with di-t-butyl peroxide (ButOOBut) in chlorobenzene at 110 deg C give rise to a series of reactions depending on the nature and the position of the substituent in the aromatic ring.When the aryl group is phenyl or p-chlorophenyl the following reactions on carbamoyl radicals occur: (i) loss of hydrogen with formation of aryl isocyanates, whereas the loss of carbon monoxide leads to arylamines via arylaminyl radicals; (ii) dimerization to NN'-diaryloxamides; (iii) aromatic substitution on chlorobenzene leading to N-arylbenzamides (ipso-substitution) and N-arylchlorobenzamides.The isocyanates trapped by t-butyl alcohol and arylamines give t-butyl N-arylcarbamates and NN'-diarylureas.With o-substituted N-phenylformamides intramolecular cyclization is observed as well; in fact, the N-(o-cyanophenyl)formamide affords isatin via addition of the carbamoyl radical to the cyano-group while the N-formamide gives 2-benzothiazolone and phenyl radicals through an SHi reaction on the sulphur atom; finally 2-formamidobiphenyls furnish phenanthridones in very high yields.
