7498-66-0

Usage

Uses

Used in Pharmaceutical Industry:
3,4'-Dichlorobenzophenone is utilized as a crucial intermediate in the synthesis of pharmaceuticals. Its chemical properties make it a valuable component in the development of new drugs and medicinal compounds.
Used in Dye Industry:
In the dye industry, 3,4'-Dichlorobenzophenone is employed as an intermediate for the production of various dyes. Its unique structure contributes to the color and stability of the dyes produced.
Used in Organic Compounds Synthesis:
3,4'-Dichlorobenzophenone is used as an intermediate in the synthesis of other organic compounds, highlighting its versatility in organic chemistry and its ability to contribute to the formation of a wide range of chemical products.
Used in Photopolymer Material Production:
As a photoinitiator, 3,4'-Dichlorobenzophenone plays a significant role in the production of photopolymer materials. Its ability to initiate polymerization reactions upon exposure to light makes it an essential component in this process.

InChI:InChI=1/C13H8Cl2O/c14-11-6-4-9(5-7-11)13(16)10-2-1-3-12(15)8-10/h1-8H

Upstream product

• 766-84-7 3-chloro-benzonitrile 
• 873-77-8 (4-chlorphenyl)magnesium bromide 
• 618-46-2 m-Chlorobenzoyl chloride 
• 108-90-7 chlorobenzene 
• 1890-28-4 divinylketone 
• 126-99-8 chloroprene 
• 7448-87-5 p-chlorophenyl vinyl ketone 
• 1679-18-1 4-Chlorophenylboronic acid 
• 145959-21-3 3-chloro-N-methoxy-N-methylbenzamide 
• 25144-36-9 (E)-2-(3-chlorophenyl)-1-(4-chlorophenyl)ethene 
• 108-37-2 1-bromo-3-chlorobenzene 
• 75748-10-6 trimethyl-4-chlorobenzoylsilane 
• 133031-82-0 C₁₇H₁₃Cl₂N₅O₃ 
• 133069-24-6 C₁₇H₁₃Cl₃N₂O₃ 

Downstream Products

• 93765-30-1 (3-Chloro-phenyl)-(4-chloro-phenyl)-pyrimidin-5-yl-methanol 
• 812684-98-3 2-(3-chloro-phenyl)-2-(4-chloro-phenyl)-[1,3]dioxolane 
• 13421-95-9 3,4'-dichlorobenzhydrol 
• 54979-73-6 N-(p-chlorophenyl)-m-chlorobenzamide 
• 13389-45-2 3,4'-dichlorobenzhydryl chloride 

Relevant academic research and scientific papers

NEW CYCLOADDUCT PRECURSORS OF DIHALOBENZOPHENONES AND PREPARATIONS THEREOF

The invention relates to new compounds of formula (I): wherein X represents a halogen atom selected from the group consisting of fluorine, chlorine, bromine and iodine, which are useful for the preparation of 4,4' dihalobenzophenones of formula (III): wherein X is as defined above.

PROCESS FOR THE PREPARATION OF DIHALOBENZOPHENONES, NEW CHEMICALS USEFUL FOR ITS IMPLEMENTATION AND METHODS FOR PREPARING SAID CHEMICALS

The invention relates to new compounds of formulae (IV), wherein X represents a halogen atom selected from the group consisting of fluorine, chlorine, bromine and iodine, said compounds being useful as precursors and/or intermediates for the preparation of 4,4'dihalobenzophenones of formula (I), wherein X is as defined above.

Pd-Catalyzed Suzuki–Miyaura Cross-Coupling of Arylboronic Acids and α-Iminonitriles through C–CN Bond Activation

A Pd-catalyzed Suzuki–Miyaura cross-coupling reaction between arylboronic acids and α-iminonitriles has been developed. The reaction proceeds through selective activation of the C–CN bond, tolerates a wide range of substituents, and delivers the versatile ketone products in moderate to excellent yields.

AZA-PYRIDONE COMPOUNDS AND USES THEREOF

Disclosed herein are aza-pyridone compounds, pharmaceutical compositions that include one or more aza-pyridone compounds, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a disease and/or a condition, including an orthomyxovirus infection, with an aza-pyridone compounds. Examples of an orthomyxovirus viral infection include an influenza infection.

Tetraethylammonium iodide catalyzed synthesis of diaryl ketones via the merger of cleavage of C-C double bonds and recombination of aromatic groups

An efficient method for synthesizing diaryl ketones via merging of oxidative cleavage of C-C double bonds and recombination of aromatic groups is developed with Et4NI (2.5 mol%) as the catalyst and NaIO4 as the oxidant. The control experiments provide valuable mechanistic insights into the formation of diaryl ketones, and suggest that NaIO4 serves as an epoxidation and nucleophilic deformylation reagent.

Reversed-polarity synthesis of diaryl ketones via palladium-catalyzed cross-coupling of acylsilanes

Acylsilanes serve as acyl anion equivalents in a palladium-catalyzed cross-coupling reaction with aryl bromides to give unsymmetrical diaryl ketones. Water plays a unique and crucial activating role in these reactions. High-throughput experimentation techniques provided successful reaction conditions initially involving phosphites as ligands. Ultimately, 1,3,5,7-tetramethyl-6-phenyl-2,4,8-trioxa-6-phosphaadamantane was identified as giving a longer-lived catalyst with higher turnover numbers. Its use, in conjunction with a palladacycle precatalyst, led to optimal reaction rates and yields. Scope and limitations of this novel method are presented along with initial mechanistic insight.

Kinetics of the solvolyses of benzhydryl derivatives: Basis for the construction of a comprehensive nucleofugality scale

A series of 21 benzhydrylium ions (diarylmethylium ions) are proposed as reference electrofuges for the development of a general nucleofugality scale, where nucleofugality refers to a combination of leaving group and solvent. A total of 167 solvolysis rate constants of benzhydrylium tosylates, bromides, chlorides, trifluoroacetates, 3,5-dinitrobenzoates, and 4-nitroben-zoates, two-thirds of which have been determined during this work, were subjected to a least-squares fit according to the correlation equation log k 25°C = Sf(Nf + Ef), where s f and Nf are nucleofuge-specific parameters and E f is an electrofuge-specific parameter. Although nucleofuges and electrofuges characterized in this way cover more than 12 orders of magnitude, a single set of the parameters, namely sf, Nf, and E f, is sufficient to calculate the solvolysis rate constants at 25°C with an accuracy of ± 16%. Because sf ≈ 1 for all nucleofuges, that is, leaving group/ solvent combinations, studied so far, qualitative discussions of nucleofugality can be based on Nf.

Process for producing p-halogenobenzophenone derivatives

The present invention provides a process for producing a p-halogenobenzophenone derivative of a high purity in a high yield at a low cost in the presence of a repeatedly usable catalyst having a long life and free from the problem of waste water treatment without using any chemical of a strong toxicity. According to the present invention, the p-halogenobenzophenone derivative is produced by reacting an (un)substituted benzotrichloride of the following formula (I) with a halogenobezene of the following formula (II) in the presence of a catalyst selected from the group consisting of alumina, nickel sulfate, zirconium oxide, amorphous silica/alumina and a mixture of two or more of them or a catalyst obtained by treating these compounds with an acid and hydrolyzing the resulting bisphenyldichloromethane of the following formula (III): STR1 wherein X represents a halogen atom or a hydrogen atom and Y represents a halogen atom.

Synthesis of 1H-1,2,4-Benzotriazepines by Intramolecular Aza-Wittig Cyclocondensation of N-(2-Acylphenyl)-C-(triphenylphosphinimido)hydrazones.

A few representatives of the title ring system have been synthesised through a reaction sequence involving an intramolecular aza-Wittig cyclocondensation of appropriately ortho-substituted N-Aryl-C-(triphenylphosphinimido)hydrazones.The cyclisation yields spread over a wide range, being markedly dependent on the substituents.

Carboxylic Trifluoromethanesulfonic Anhydrides as Highly Effective Acylation Agents. - Perfluoroalkanesulfonic Acid Catalyzed Acylation of Arenes

Arene- and alkanecarboxylic trifluoromethanesulfonic anhydrides 2 and 5 are highly effective acylation agents, which react without Friedel-Crafts catalysts even with deactivated aromatics to yield aryl ketones 3 and 6, respectively.Acylation of arenes with carbonyl chlorides 4 and catalytic amounts of perfluoroalkanesulfonic acid gives ketones 3 and 6, resp., in good yields.Under similar conditions other strong Broensted acids show a considerably smaller degree of catalytic effect.