54985-61-4Relevant articles and documents
Synthesis, cytotoxic activity, DNA binding and molecular docking studies of novel 9-anilinothiazolo[5,4-b]quinoline derivatives
Reyes-Rangel, Francisco J.,López-Rodríguez, A. Kémish,Pastrana-Cancino, Laura V.,Loza-Mejía, Marco. A.,Solano, José D.,Rodríguez-Sotres, Rogelio,Lira-Rocha, Alfonso
, p. 2976 - 2988 (2016/11/09)
Novel thiazolo[5,4-b]quinoline derivatives were prepared with or without a (2-(azacycloalkyl)ethyl)amino substituent at the 2-position. The effect of the substituent at 2-position on cytotoxic activity, DNA-intercalation and cytotoxic properties were evaluated. Substituents at 2-position bearing an aliphatic amine favored cytotoxicity, while removal of these substituents resulted in low or negligible cytotoxic properties. Additionally, the in silico predicted binding mode of the novel compounds into DNA correlated with the experimental intercalation data. These results suggest a strong influence of the substituent at 2-position on the DNA intercalation properties.
Synthesis of condensed pyrimidines in one-pot reaction from pyranoquinolines and BMMAs
Nahas, Nariman M.
, p. 51 - 54 (2008/09/19)
New pentacyclic heterocycles of the type 3a-e -5a-e were synthesized by one - pot reaction of the amino-cyano pyrano[3,2-h]quinolines la-e with BMMAs ( e.g. Ethyl N-[bis (methylsulfanyl) methylene] glycinate, ethyl 2[bis (methylsulfanyl) methylene]-1-methylhydrazine carboxylate and / or ethyl N[bis(methylsulfanyl) methylene]- ss-alaninate). All the synthesized derivatives were identified by conventional methods (IR, 1HNMR, MS) and elemental analysis. Antifungal tests were also performed.
Fused pyrimidines. Part II: Synthesis and antimicrobial activity of some furo[3,2-e]imidazo[1,2-c]pyrimidines and furo[2,3-d]pyrimidines
Bhuiyan,Rahman, Khandker M. M.,Hossain,Rahim,Hossain
, p. 633 - 636 (2007/10/03)
2-Amino-4,5-diphenylfuran-3-carbonitrile (2) reacted with N-[bis(methylthio)methylene]glycine ethyl ester (1) to afford a double cyclized product 5-methylthio-8,9-diphenylfuro[3,2-e]imidazo[1,2-c]pyrimidin-2(3H)-one (3). Compound 2 also reacts with benzon
Annelated pyrrolo-pyrimidines from amino-cyanopyrroles and BMMAs as leads for new DNA-interactive ring systems
Lauria, Antonino,Bruno, Marcella,Diana, Patrizia,Barraja, Paola,Montalbano, Alessandra,Cirrincione, Girolamo,Dattolo, Gaetano,Almerico, Anna Maria
, p. 1545 - 1553 (2007/10/03)
The efficient one-pot synthesis of several new tricyclic systems of type 1 and 2, obtained from the reaction of substituted 2-amino-3-cyanopyrroles and 3-amino-4-cyanopyrroles with BMMAs, is reported. The duration and yields of the reaction strongly depen
Triphosgene: A versatile reagent for the synthesis of azetidin-2-ones
Krishnaswamy,Govande,Gumaste,Bhawal,Deshmukh
, p. 2215 - 2225 (2007/10/03)
An efficient use of triphosgene, as an acid activator, for the synthesis of substituted azetidin-2-ones via ketene-imine cycloaddition reaction using various acids and imines have been described.
N-AMINO ESTERS (BMMA): NOVEL REAGENTS FOR ANNELATION OF PYRIMIDINE MOIETIES
Sauter, Fritz,Froehlich, Johannes,Blasl, Karin,Gewald, Karl
, p. 851 - 866 (2007/10/02)
New reagents for heterocyclic annelations containing a N-amino moiety (=BMMA) were developed and studied regarding their scope and limitations: one-pot reaction with (hetero)aromatic ortho-aminocarbonyl-type model compounds ("car
Synthesis of 4-Unsubstituted β-Lactams via Dithiocarbonimidates
Sharma, S. D.,Mehra, Usha,Khurana, J. P. S.,Pandhi, S. B.
, p. 990 - 992 (2007/10/02)
Cycloaddition of dithiocarbonimidate 1 to the ketene generated in situ from phenoxyacetylchloride in the presence of triethylamine affords the 4-dithioalkyl-2-azetidinones 2 in good yields.Facile conversion of 2 to the 4-unsubstituted β-lactams 3 can be accomplished by desulfurization with Raney-Nickel.Formation of several interesting products during attempts to bring a carbonyl function at C-4 in 2 has also been described.
A NOVEL SYNTHESIS OF THIAZOLES FROM DIMETHYL N-(ETHOXYCARBONYLMETHYL)IMINO DITHIOCARBONATE, CARBON DISULFIDE AND ALKYL HALIDES
Alvarez-Ibarra, C.,Davila, E.,Mateo, A.,Ortiz, P.,Quiroga, M. L.
, p. 6667 - 6670 (2007/10/02)
We report a new synthesis of thiazoles from a cyclocondensation reaction between dimethyl N-(ethoxycarbonylmethyl)iminodithiocarbonate (EMIC), carbon disulfide and alkylation of intermediate thiazole-2-thiolate with alkyl halides.
A NOVEL SYNTHESIS OF 2,3-DIHYDROOXAZOLES FROM DIMETHYL N-ETHOXYCARBONYLMETHYLIMINODITHIOCARBONATE AND AROMATIC ALDEHYDES
Ibarra, Alvarez C.,Cereceda, J. A.,Ortiz, P.,Vicente, A.,Quiroga, M. L.
, p. 243 - 246 (2007/10/02)
We report the synthesis of 5-aryl-2-ethoxycarbonyl-4-methylthio-2,3-dihydrooxazoles from a cyclocondensation reaction between dimethyl N-ethoxycarbonylmethyliminodithiocarbonate and aromatic aldehydes.