5499-28-5

Basic information

• Product Name: 1-Benzimidazoleethanol,alpha,2-dimethyl-(7CI,8CI)
• Synonyms: 1-Benzimidazoleethanol,alpha,2-dimethyl-(7CI,8CI)
• CAS NO: 5499-28-5
• Molecular Formula: C11H14N2O
• Molecular Weight: 190.24166
• Product Categories: BENZIMIDAZOLE
• Mol File: 5499-28-5.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-Benzimidazoleethanol,alpha,2-dimethyl-(7CI,8CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Benzimidazoleethanol,alpha,2-dimethyl-(7CI,8CI)(5499-28-5)
• EPA Substance Registry System: 1-Benzimidazoleethanol,alpha,2-dimethyl-(7CI,8CI)(5499-28-5)

Safety Data

• Hazardous Substances Data: 5499-28-5(Hazardous Substances Data)

Usage

Appearance

White to off-white solid

Molecular weight

190.24 g/mol

Usage

Synthesis and production of various pharmaceuticals and organic compounds; intermediate in the production of other chemicals

Pharmacological activity

Potential pharmacological activity

Safety measures

Handled and used with appropriate safety measures to avoid potential hazards

Upstream product

• 2033-54-7 methyl 2-acetate 
• 615-15-6 2-Methyl-1H-benzimidazole 

Relevant articles and documents

Lipase-Catalyzed Kinetic Resolution of Novel Antifungal N-Substituted Benzimidazole Derivatives

A series of new N-substituted benzimidazole derivatives was synthesized and their antifungal activity against Candida albicans was evaluated. The chemical step included synthesis of appropriate ketones containing benzimidazole ring, reduction of ketones to the racemic alcohols, and acetylation of alcohols to the esters. All benzimidazole derivatives were obtained with satisfactory yields and in relatively short times. All synthesized compounds exhibit significant antifungal activity against Candida albicans 900028 ATCC (% cell inhibition at 0.25 μg concentration > 98%). Additionally, racemic mixtures of alcohols were separated by lipase-catalyzed kinetic resolution. In the enzymatic step a transesterification reaction was applied and the influence of a lipase type and solvent on the enantioselectivity of the reaction was studied. The most selective enzymes were Novozyme SP 435 and lipase Amano AK from Pseudomonas fluorescens (E > 100).