5499-69-4Relevant academic research and scientific papers
Facile microwave assisted decarbonylation of 4-formyl group in 5-alkyl amino substituted pyrazoles
Sakya, Subas M.,Abrams, Barbara,Snow, Sheri L.,Rast, Bryson
, p. 2280 - 2282 (2008/09/18)
Facile decarbonylation of the 4-formyl group in 5-alkyl amino pyrazoles was seen when reacted with catalytic p-toluene sulfonic acid in methanol under microwave irradiation to provide parent 4-H pyrazoles in good yields.
Introduction of N-containing heterocycles into pyrazole by nucleophilic aromatic substitution
Park, Min-Sup,Park, Hyun-Ja,Park, Koon Ha,Lee, Kee-In
, p. 1541 - 1550 (2007/10/03)
The nucleophilic aromatic substitution on 5-chloropyrazoles activated by the electron-withdrawing formyl group offers a useful method to introduce a wide range of N-containing heterocycles into them. The rate of reaction was greatly affected by the electronic nature of the N-1 substitution.
