55009-95-5Relevant academic research and scientific papers
Efficient trifluoromethylation of activated and non-activated alkenyl halides by using (trifluoromethyl)trimethylsilane
Hafner, Andreas,Braese, Stefan
scheme or table, p. 3044 - 3048 (2012/01/02)
An efficient method for the trifluoromethylation of halogenated double bonds by using in situ generated "trifluoromethyl copper" is described. Herein, the most common trifluoromethyl source, (trifluoromethyl) trimethylsilane, was converted selectively int
A NOVEL AND CONVENIENT METHOD FOR TRIFLUOROMETHYLATION OF ORGANIC HALIDES USING CF3SiR'3/KF/Cu(I) SYSTEM
Urata, Hisao,Fuchikami, Takamasa
, p. 91 - 94 (2007/10/02)
Fluoride ion induced cross-coupling reaction of organic halides with trifluoromethyltrialkylsilanes takes place in the presence of Cu(I) salts under mild reaction conditions to give the corresponding trifluoromethylated products in high yields.
Sodium Perfluoroalkane Carboxylates as Sources of Perfluoroalkyl Groups
Carr, Gillian E.,Chambers, Richard D.,Holmes, Thomas F.,Parker, David G.
, p. 921 - 926 (2007/10/02)
Sodium trifluoroacetate, in the presence of copper(I) iodide, is used as a source of trifluoromethyl to replace halogen by trifluoromethyl in benzenoid and heterocyclic aromatic systems, as well as in alkenyl and alkyl halogen compounds.The mechanism of this interesting copper-assisted process has been explored and an intermediate of the form - is proposed.Introduction of higher perfluoroalkyl groups from their respective sodium perfluoroalkane carboxylates has been demonstrated and the machanistic features are compared with those of the trifluoromethylation process.
