55032-35-4Relevant academic research and scientific papers
Solution-phase and solid-phase syntheses of enzyme inhibitor RK-682 and antibiotic agglomerins
Schobert, Rainer,Jagusch, Garsten
, p. 6129 - 6132 (2007/10/03)
The enzyme inhibitor RK-682 (5A)-(+)-1 was prepared in solution and on a solid support from (2R)-glycerates in five steps and ca. 40% overall yield. Key steps were a ring-closing tandem addition-Wittig alkenation reaction of the respective protected or im
Synthesis and CB1 receptor activities of novel arachidonyl alcohol derivatives
Parkkari, Teija,Savinainen, Juha R.,Rauhala, Anu L.,Tolonen, Tiina L.,Nevalainen, Tapio,Laitinen, Jarmo T.,Gynther, Jukka,Jaervinen, Tomi
, p. 3231 - 3234 (2007/10/03)
Novel derivatives of arachidonyl alcohol were synthesized and evaluated for their CB1 receptor activity by [35S]GTPγS assay using rat cerebellar membranes.
Chemical and Electrochemical Asymmetric Dihydroxylation of Olefins in I2-K2CO3-K2OsO2(OH)4 and I2-K3PO4/K2HPO4-K2OsO2(OH)4 Systems with Sharpless' Ligand
Torii, Sigeru,Liu, Ping,Bhuvaneswari, Narayanaswamy,Amatore, Christian,Jutand, Anny
, p. 3055 - 3060 (2007/10/03)
Iodine-assisted chemical and electrochemical asymmetric dihydroxylation of various olefins in I2-K2CO3-K2OsO2(OH)4 and I2-K3PO4/K2HPO4-K2OsO2(OH)4 systems with Sharpless' ligand provided the optically active glycols in excellent isolated yields and high enantiomeric excessses.Iodine (I2) was used stoichiometrically for the chemical dihydroxylation, and good results were obtained with nonconjugated olefins in contrast to the case of potassium ferricyanide as a co-oxidant.The potentialily of I2 as a co-oxidant under stoichiometric conditions has been proven to be effective as an oxidizing mediator in electrolysis systems.Iodine-assited asymmetric electro-dihydroxylation of olefins in either a t-BuOH/H2O(1/1)-K2CO3/(DHQD)2PHAL-(Pt) or t-BuOH/H2O(1/1)-K3PO4/K2HPO4/(DHQD)2PHAL-(Pt) system in the presence of potassium osmate in an undivided cell was investigated in detail.Irrespective of the substitution pattern, all the olefins afforded the diols in high yields and excellent enantiomeric excesses.A plausible mechanism is discussed on the basis of cyclic voltammograms as well as experimental observations.
Eine neue Ligandenklasse fuer die asymmetrische Dihydroxylierung von Olefinen
Becker, Heinrich,Sharpless, K. Barry
, p. 447 - 449 (2007/10/03)
Keywords: Asymmetrische Dihydroxylierungen; Chirale Liganden; Chinchonaalkaloide; Katalyse; Osmiumverbindungen
The Osmium-Catalyzed Asymmetric Dihydroxylation: A New Ligand Class and a Process Improvement
Sharpless, K. Barry,Amberg, Willi,Bennani, Youssef L.,Crispino, Gerard A.,Hartung, Jens,et al.
, p. 2768 - 2771 (2007/10/02)
Two key improvements in the osmium-catalyzed asymmetric dihydroxylation have led to a simple procedure which is applicable to a wide range of olefins.
