550372-57-1Relevant academic research and scientific papers
Dimethoxybenzo[i]phenanthridine-12-carboxylic acid derivatives and 6H-dibenzo[c,h][2,6]naphthyridin-5-ones with potent topoisomerase I-targeting activity and cytotoxicity
Ruchelman, Alexander L.,Zhu, Shejin,Zhou, Nai,Liu, Angela,Liu, Leroy F.,LaVoie, Edmond J.
, p. 5585 - 5589 (2004)
The exceptional TOP1-targeting activity and antitumor activity of ARC-111, 1, prompted studies on similarly substituted benzo[i]phenanthridine-12- carboxylic ester and amide derivatives. These studies were extended to include 6-substituted 8,9-dimethoxy-2
6-Substituted 6H-dibenzo[c,h][2,6]naphthyridin-5-ones: Reversed lactam analogues of ARC-111 with potent topoisomerase I-targeting activity and cytotoxicity
Zhu, Shejin,Ruchelman, Alexander L.,Zhou, Nai,Liu, Angela,Liu, Leroy F.,LaVoie, Edmond J.
, p. 3131 - 3143 (2007/10/03)
6-Substituted 8,9-dimethoxy-2,3-methylenedioxy-6H-dibenzo[c,h][2,6] naphthyridin-5-ones were synthesized and evaluated for topoisomerase I-targeting activity and cytotoxicity. Several of these reversed lactam analogues of ARC-111 exhibited exceptional cyt
