383875-59-0

Basic information

• Product Name: 1H-Pyrrolo[2,3-b]pyridine-3-carboxaldehyde, 6-chloro-
• Synonyms: 1H-Pyrrolo[2,3-b]pyridine-3-carboxaldehyde, 6-chloro-;6-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde;1H-Pyrrolo[2,3-b]pyridine-3-carbaldehyde, 6-chloro-;6-Chloro-7-azaindole-3-carbaldehyde
• CAS NO: 383875-59-0
• Molecular Formula: C8H5ClN2O
• Molecular Weight: 180.59
• Product Categories: Heterocycle-Pyridine series
• Mol File: 383875-59-0.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 387°C at 760 mmHg
• Flash Point: 187.9°C
• Appearance: /
• Density: 1.521g/cm³
• Vapor Pressure: 3.39E-06mmHg at 25°C
• Refractive Index: 1.748
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 11.48±0.40(Predicted)
• CAS DataBase Reference: 1H-Pyrrolo[2,3-b]pyridine-3-carboxaldehyde, 6-chloro-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrrolo[2,3-b]pyridine-3-carboxaldehyde, 6-chloro-(383875-59-0)
• EPA Substance Registry System: 1H-Pyrrolo[2,3-b]pyridine-3-carboxaldehyde, 6-chloro-(383875-59-0)

Safety Data

• Hazardous Substances Data: 383875-59-0(Hazardous Substances Data)

Usage

General Description

1H-Pyrrolo[2,3-b]pyridine-3-carboxaldehyde, 6-chloro- is a chemical compound with the molecular formula C9H6ClNO. It is a yellow crystalline solid with a faint odor, and it is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. 1H-Pyrrolo[2,3-b]pyridine-3-carboxaldehyde, 6-chloro- has a diverse range of applications, including as a building block in the production of various organic compounds and as a reagent in chemical reactions. It is important to handle and store this chemical carefully, as it can be harmful if ingested, inhaled, or in contact with the skin, and it may also cause irritation to the eyes and respiratory system.

InChI:InChI=1/C8H5ClN2O/c9-7-2-1-6-5(4-12)3-10-8(6)11-7/h1-4H,(H,10,11)

Upstream product

• 100-97-0 hexamethylenetetramine 
• 108-24-7 acetic anhydride 
• 55052-27-2 6-chloro-7-azaindole 
• 64-19-7 acetic acid 
• 143468-07-9 6-Chloro-1-methoxycarbonyl-1H-pyrrolo<2,3-b>pyridine 
• 55052-24-9 1H-Pyrrolo[2,3-b]pyridine-7-oxide 

Relevant articles and documents

Design and Synthesis of Potent and Selective PIM Kinase Inhibitors by Targeting Unique Structure of ATP-Binding Pocket

In the development of kinase inhibitors, one of the major concerns is selectivity. An effective strategy to achieve high selectivity is to utilize structural differences among kinases to inform inhibitor design. Here, we set out to improve the PIM (proviral integration site for Moloney murine leukemia virus) kinase-inhibitory selectivity of our previously reported 7-azaindole derivative 2, which has promising ADMET properties, by targeting a unique bulge in the ATP-binding pocket. 6-Substituted 7-azaindoles, especially the 6-chlorinated derivatives, proved to be potent and selective PIM kinase inhibitors and appear to be promising lead compounds for future drug discovery.

NEW IMIDAZOLONE DERIVATIVES, PREPARATION THEREOF AS DRUGS, PHARMACEUTICAL COMPOSITIONS, AND USE THEREOF AS PROTEIN KINASE INHIBITORS, IN PARTICULAR CDC7

The present invention relates to imidazolone derivatives of formula (I) to methods of preparing such derivatives, intermediates thereto, pharmaceutical compositions comprising such derivatives, and methods of inhibiting protein kinase, and methods of treatment comprising administration of such derivatives.