55095-21-1

Basic information

• Product Name: 4-methylbenzhydrylamine
• Synonyms: (4-methylphenyl)-phenyl-methanamine hydrochloride;[(4-methylphenyl)-phenylmethyl]azanium chloride;[(4-methylphenyl)-phenyl-methyl]azanium chloride;[phenyl-(p-tolyl)methyl]amine hydrochloride;[phenyl-(p-tolyl)methyl]ammonium chloride;phenyl-(p-tolyl)methanamine hydrochloride;phenyl(p-tolyl)methanamine hydrochloride;4-methylbenzhydrylamine
• CAS NO: 55095-21-1
• Molecular Formula: C₁₄H₁₅N
• Molecular Weight: 197.28
• Mol File: 55095-21-1.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 320.8°C at 760 mmHg
• Flash Point: 151.5°C
• Appearance: /
• Density: 1.04g/cm³
• Vapor Pressure: 0.00031mmHg at 25°C
• Refractive Index: 1.589
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-methylbenzhydrylamine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-methylbenzhydrylamine(55095-21-1)
• EPA Substance Registry System: 4-methylbenzhydrylamine(55095-21-1)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 55095-21-1(Hazardous Substances Data)

Usage

General Description

4-methylbenzhydrylamine is an organic compound with the formula C15H17N. It is a derivative of benzhydrylamine, containing a methyl group attached to the benzene ring. This chemical is commonly utilized as a precursor in the synthesis of various pharmaceuticals and organic compounds. It is also used as a reagent in chemical reactions, particularly in the formation of carbon-carbon and carbon-nitrogen bonds. Due to its structural features, 4-methylbenzhydrylamine exhibits a range of biological and pharmacological activities, including potential antihistaminic and antihypertensive effects, making it a significant molecule in medicinal and synthetic chemistry research.

InChI:InChI=1/C14H15N/c1-11-7-9-13(10-8-11)14(15)12-5-3-2-4-6-12/h2-10,14H,15H2,1H3

Upstream product

• 100-47-0 benzonitrile 
• 134-84-9 4-Methylbenzophenone 
• 104-85-8 para-methylbenzonitrile 
• 108-86-1 bromobenzene 
• 960-71-4 triphenylborane 
• 22632-90-2 4-methyl-benzophenone-imine 
• 38032-15-4 (4-methylphenyl)phenylmethanone oxime 
• 1517-63-1 4-methylphenyl(phenyl)methanol 

Downstream Products

• 5267-50-5 N-[(4-methylphenyl)(phenyl)methyl]acetamide 
• 133175-58-3 (R)-2-Fluoro-2-phenyl-N-((R)-phenyl-p-tolyl-methyl)-acetamide 
• 133175-66-3 (R)-2-Fluoro-2-phenyl-N-((S)-phenyl-p-tolyl-methyl)-acetamide 
• 69790-42-7 N-(4-Methyl)benzhydrylimin v. Benzaldehyd 
• 5267-49-2 (RS)-(4-methylphenyl)phenylmethylamine hydrochloride 
• 1193086-58-6 N-[(4-methylphenyl)(phenyl)methyl]-1-phenyl-4-[(E)-2-(5-phenyl-1,3,4-oxadiazol-2-yl)ethenyl]-1H-pyrazole-3-carboxamide 
• 1422166-92-4 C₂₉H₂₆N₂O₃ 
• 134-84-9 4-Methylbenzophenone 
• 394729-62-5 (C₅H₅)Fe(C₅H₃)(P(C₆H₄CF₃-p)2)(CHNCH(C₆H₄CH₃-p)Ph) 
• 394729-59-0 (C₅H₅)Fe(C₅H₃)(PPh₂)(CHNCH(C₆H₄CH₃-p)Ph) 
• 620-83-7 1-methyl-4-(phenylmethyl)benzene 
• 170459-31-1 phenyl-p-tolylmethyl isocyanate 
• 71136-01-1 (4-methyl-benzhydryl)-urea 
• 71292-58-5 N-(4-methyl-benzhydryl)-glycine 

Relevant articles and documents

Synthesis, characterization and antibacterial effect of diarylmethylamine-based imines

Firstly, starting from benzoic acid the diarylmethanone compound was synthesized. The diarylmethanone was converted to the corresponding oxime and then reduced to the diarylmethylamine compound. Four different imine compounds were obtained from the condensation of the diarylmethylamine compound with four different salicylaldehyde derivatives. Antimicrobial activities against Gram (+) and Gram (?) microorganisms (Staphylococcus aureus, Bacillus cereus as the Gram (+); Escherichia coli and Salmonella typhimurium as the Gram (?); and Candida albicans as the fungi) were investigated.

Palladium-catalyzed benzylic arylation of N-benzylxanthone imine

(Chemical Equation Presented) The direct benzylic arylation of N-benzylxanthone imine with aryl chloride proceeds under palladium catalysis, yielding the corresponding coupling product. The product is readily transformed to benzhydrylamine. Taking into consideration that the imine is readily available from benzylic amine, the overall transformation represents a formal cross-coupling reaction of aryl halide with α-aminobenzyl metal.

Synthesis of substituted benzhydrylamines

The synthesis of para di- and monosubstituted benzhydrylamines by addition of Grignard reagents to benzonitriles and subsequent reduction, is evaluated and discussed. The reduction step with sodium borohydride allows simple handling and mild conditions. An optimized synthesis of 4,4'-dimethoxybenzhydrylamine by this method is disclosed.