5267-50-5

Upstream product

• 507-09-5 thioacetic acid 
• 28380-81-6 4-methyl-benzhydryl isothiocyanate 
• 55095-21-1 phenyl-p-tolylmethylamine 
• 108-24-7 acetic anhydride 
• 1517-63-1 4-methylphenyl(phenyl)methanol 
• 75-05-8 acetonitrile 
• 75-36-5 acetyl chloride 
• 620-83-7 1-methyl-4-(phenylmethyl)benzene 
• 1309582-76-0 N,N'-sulfonyl bis-[(4-fluorophenyl)(4-methylphenyl)methanamine] 
• 1309582-70-4 N,N'-sulfonyl bis-[(4-methylphenyl)(phenyl)methylamine] 
• 24388-23-6 2-phenyl-4,4,5,5-tetramethyl-1,3,2-dioxoborole 
• 87100-32-1 2-[chloro(phenyl)methyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 867182-05-6 N-[phenyl(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methyl]acetamide 
• 106-38-7 para-bromotoluene 

Relevant academic research and scientific papers

Chemoselective formation of C–N bond in wet acetonitrile using amberlyst-15(H) as a recyclable catalyst

An economically efficient and environmentally benign protocol for the chemoselective one-pot synthesis of diversely N-substituted amides has been developed in good yield through the reaction of benzylic secondary alcohols as well as aliphatic tertiary alcohols and alkyl/aryl nitriles. Commercially available Amberlyst-15(H) has been utilized at 80 °C as an air-stable and reusable heterogeneous inexpensive solid acid catalyst without any anhydrous and inert environment. The attractive features of the present synthetic protocol are mild reaction conditions, short reaction time, excellent chemoselectivity, high atom economy and tolerance of various sensitive moieties.

Manganese(III) acetate catalyzed oxidative amination of benzylic C(sp3)-H bonds with nitriles

Mn-Catalyzed oxidative amination of benzylic C(sp3)-H bonds with nitriles is disclosed, which enables the synthesis of a broad range of secondary amides in moderate to excellent yields under mild conditions. The interaction between Mn(iii) and DDQ facilitates the oxidation and makes it highly efficient and selective.

Method for preparing amide from aryl methane derivative and nitrile

The invention provides a simple and efficient method for directly preparing an amide compound from an aryl methane derivative and nitrile. In the method, manganese triacetate dihydrate is used as a catalyst, and 2,3-dichloro-5,6-dicyano-1,4-benzoquinone(DDQ) is used as an oxidizing agent. The method has the characteristics that raw materials are cheap and easy to obtain, the source of the nitrile is wide, reaction conditions are mild, the applicability is wide and the like. The method solves the problems that ceric ammonium nitrate (CAN) and a fluorine agent which are used by a method for directly synthesizing amide by using aryl methane and nitrile compounds are hard to treat, atomic economy is poor, the source of the nitrile is narrow and the like.

Bis-sulfamyl imines: Potent substrates for asymmetric additions of arylboroxines under rhodium catalysis

Bis-sulfamyl imines are shown to be potentially ideal substrates for rhodium-catalysed asymmetric additions of arylboron nucleophiles as they show: (i) near perfect enantioselectivities (11 examples, 98-99+% ee), (ii) good to excellent diastereoselectivities (10-32:1 rac:meso), and (iii) high functional group tolerance in removal of the low molecular weight protecting group via mild heating in aqueous pyridine.

α-Amidobenzylation of aryl and alkenyl halides via palladium-catalyzed Suzuki-Miyaura coupling with α-(acylamino) benzylboronic esters

The Suzuki-Miyaura coupling of α-(acetylamino)benzylboronic esters with aryl and alkenyl halides has been achieved using a Pd/P(t-Bu)3 catalyst with KF and H2O in 1,4-dioxane, giving α-substituted benzylamines in high yields. Copyright

Palladium-catalyzed benzylic arylation of N-benzylxanthone imine

(Chemical Equation Presented) The direct benzylic arylation of N-benzylxanthone imine with aryl chloride proceeds under palladium catalysis, yielding the corresponding coupling product. The product is readily transformed to benzhydrylamine. Taking into consideration that the imine is readily available from benzylic amine, the overall transformation represents a formal cross-coupling reaction of aryl halide with α-aminobenzyl metal.

Iron(III) perchlorate - A novel reagent in synthesis

Iron (III) perchlorate in acetonitrile as the solvent converts alkohols and alkyl halides to acetamide derivatives, cleaves glycols and converts α-hydroxy acids to aldehydes or ketones.

A Conceptually New Approach to the Synthesis of Secondary Amides and Thioamides

Amides and thioamides of type RC(=X)NHCHR1R2 are prepared in high yield with the formation of a new C-R2 bond by the action of a Grignard reagent (R2MgX) on the readily available adducts from an amide RCONH2 (or thioamide RCSNH2), aldehyde R1CHO, and benzotriazole.