55095-22-2

Basic information

• Product Name: 1,1-bis(4-methylphenyl)methanamine
• Synonyms: 1,1-bis(4-methylphenyl)methanamine;4-METHYL-ALPHA-(4-METHYLPHENYL)-BENZENEMETHANAMINE;DI-P-TOLYLMETHANAMINE
• CAS NO: 55095-22-2
• Molecular Formula: C₁₅H₁₇N
• Molecular Weight: 211.306
• Mol File: 55095-22-2.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 339.5±11.0 °C(Predicted)
• Appearance: /
• Density: 1.026±0.06 g/cm3(Predicted)
• PKA: 8.74±0.10(Predicted)
• CAS DataBase Reference: 1,1-bis(4-methylphenyl)methanamine(CAS DataBase Reference)
• NIST Chemistry Reference: 1,1-bis(4-methylphenyl)methanamine(55095-22-2)
• EPA Substance Registry System: 1,1-bis(4-methylphenyl)methanamine(55095-22-2)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 55095-22-2(Hazardous Substances Data)

Usage

General Description

1,1-bis(4-methylphenyl)methanamine, also known as 1,1-bis(4-tolyl)ethanamine, is a chemical compound with the molecular formula C15H17N. It is an organic compound that belongs to the class of amines, which are compounds containing an amino group (NH2) connected to a carbon atom. This particular compound is a substituted aniline derivative with two methylphenyl (tolyl) groups attached to a central carbon atom. It is commonly used as an intermediate in the synthesis of pharmaceuticals and organic compounds. 1,1-bis(4-methylphenyl)methanamine has a variety of industrial applications, including as a raw material in the production of dyes, polymers, and other specialty chemicals. It is important to handle this compound with care, as it can pose health hazards if not properly managed.

Upstream product

• 44398-45-0 N-dichloromethyl-formamidine 
• 13389-70-3 bis(4-methylphenyl)methyl chloride 
• 4957-14-6 4,4'-dimethyldiphenylmethane 
• 29559-27-1 1-methyl-4-(nitromethyl)benzene 
• 104-85-8 para-methylbenzonitrile 
• 106-38-7 para-bromotoluene 
• 114583-47-0 benzophenone N,N,N-trimethylhydrazonium iodide 
• 4294-57-9 para-methylphenylmagnesium bromide 
• 25891-29-6 tris(dichloromethyl)amine 
• 108-88-3 toluene 
• 885-77-8 4,4'-dimethylbenzhydrol 
• 611-97-2 bis(p-methylphenyl)-methanone 
• 16620-75-0 4,4'-dimethylbenzophenone imine 
• 1714-49-4 4,4'-dimethyl-benzophenone oxime 

Downstream Products

• 205874-88-0 N-(N^α-t-butoxycarbonyl-N^g-tosylarginyl)bis(4-methylphenyl)methanamine 
• 1581274-94-3 C₂₂H₂₃NO₂S 
• 1101850-33-2 (S)-N-{(R)-2-[bis(p-methylphenyl)methylamino]-2-phenylethyl}prolinol 
• 205875-00-9 N-(N^α-benzyloxycarbonyl-N^α-methyl-O-benzyltyrosyl-N^g-tosylarginyl)bis(4-methylphenyl)methanamine 
• 611-97-2 bis(p-methylphenyl)-methanone 
• 4957-14-6 4,4'-dimethyldiphenylmethane 
• 78817-21-7 Benzil bis(4,4'-dimethylbenzhydrylimine) 
• 78817-22-8 2,3-diphenyl-5,6-di-(4-methylphenyl)pyrazine 
• 69790-44-9 Benzaldehyde N-(4,4'-dimethyl)-benzhydrylimine 
• 5267-52-7 N-(di-p-tolylmethyl)acetamide 
• 1421837-11-7 N-(di-p-tolylmethyl)-2-(4-((3,5-dimethylisoxazol-4-yl)methoxy)phenyl)acetamide 

Relevant articles and documents

Electrochemical Oxidative C(sp3)-H/N-H Coupling of Diarylmethanes with Sulfoximines or Benzophenone Imine

Herein, we report an efficient electrochemical method for the synthesis of N-alkylated sulfoximines by electrochemical oxidative C(sp3)-H/N-H coupling of sulfoximines and diarylmethanes. In addition, we used the same conditions for electrochemical dehydrogenative amination of diarylmethanes with benzophenone imine as an aminating agent. The reactions showed good functional group tolerance and afforded the corresponding products in moderate to good yields without the use of a stoichiometric oxidant, a metal catalyst, or an activating agent.

Palladium-Catalyzed α-Arylation of Aryl Nitromethanes

Catalytic conditions for the α-arylation of aryl nitromethanes have been discovered using parallel microscale experimentation, despite two prior reports of the lack of reactivity of these aryl nitromethane precursors. The method efficiently provides a variety of substituted, isolable diaryl nitromethanes. In addition, it is possible to sequentially append two different aryl groups to nitromethane. Mild oxidation conditions were identified to afford the corresponding benzophenones via the Nef reaction, and reduction conditions were optimized to afford several diaryl methylamines.

COMPOUNDS AND METHODS

The present invention relates to novel retinoid-reiated orphan receptor gamma (RORy) modulators and their use in the treatment of diseases mediated by RORy.