5510-82-7Relevant academic research and scientific papers
Chloroform-based Atherton-Todd-type reactions of alcohols and thiols with secondary phosphine oxides generating phosphinothioates and phosphinates
Li, Shan,Chen, Tieqiao,Saga, Yuta,Han, Li-Biao
, p. 71544 - 71546 (2015)
Chloroform-based Atherton-Todd-type reactions of alcohols and thiols with secondary phosphine oxides, generating phosphinothioates and phosphinates, respectively, are described. Various valuable phosphinothioates and phosphinates including those with functional groups are readily prepared under mild reaction conditions.
Green synthetic method of thiohypophosphate
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Paragraph 0082-0085, (2019/10/29)
The invention relates to a green synthetic method of thiohypophosphate as shown in the formula I as show in the specification, wherein R is phenyl, not more than three methyl or three methoxyl or three halogen substituted phenyl, straight-chain or branch-chain alkyl with no more than six carbon atoms, straight-chain or branch-chain alkenyl with no more then six carbon atoms, straight-chain or branch-chain alkynyl with no more than six carbon atoms and a 3 to 8-member aliphatic ring group; R is phenyl, not more than three methyl or three methoxyl or three halogen substituted phenyl, pyridyl, benzyl, naphthyl and a 3 to 8-member aliphatic ring group; according to the synthetic method, thiohypophosphate is a product directly obtained by enabling N-R thiophthalimide to react with di-R based phosphine oxide with water as a solvent.
Dimethyl sulfoxide as a mild oxidant in S-P(O) bond construction: Simple and metal-free approaches to phosphinothioates
Sun, Jian-Guo,Weng, Wei-Zhi,Li, Ping,Zhang, Bo
supporting information, p. 1128 - 1133 (2017/08/18)
In the presence of dimethyl sulfoxide (DMSO) as a mild oxidant and reaction medium, a simple and efficient protocol has been developed for the preparation of phosphinothioates via oxidative dehydrogenative phosphorylation of thiols with P(O)H compounds. Additionally, a DMSO-mediated oxidative phosphorylation of disulfides is also demonstrated. Notably, these transformations occur efficiently without the help of any transition metal or additive. These reactions are easy to conduct and can be scaled-up, and various phosphinothioates are readily obtained in moderate to excellent yields with excellent chemoselectivity and good functional-group tolerance.
Direct synthesis of thiophosphates by reaction of diphenylphosphine oxide with sulfonyl chlorides
He, Wei,Wang, Zhiming,Li, Xinjin,Yu, Qing,Wang, Zhongwei
, p. 7594 - 7598 (2016/11/11)
A new method for the synthesis of thiophosphates by reductive coupling reaction of diphenylphosphine oxide and sulfonyl chlorides has been developed. The reaction is metal-free and needs no additives, affording various aryl and alkyl substituted thiophosphates in good to excellent yields under mild conditions.
Metal-Free Visible-Light-Mediated Oxidative Cross-Coupling of Thiols with P(O)H Compounds Using Air as the Oxidant
Sun, Jian-Guo,Yang, Hua,Li, Ping,Zhang, Bo
supporting information, p. 5114 - 5117 (2016/10/14)
Visible light along with 5 mol % of rose bengal catalyzes the direct S-P(O) coupling between thiols and P(O)H compounds in the presence of air as the green oxidant. The protocol is operationally simple and amenable to gram-scale synthesis. A variety of S-
